75907-18-5

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 123-54-6 acetylacetone 
• 570-08-1 diethyl acetylmalonate 
• 137786-67-5 ethyl 3-amino-2-ethoxycarbonyl-2-butenoate 
• 201230-82-2 carbon monoxide 
• 5720-07-0 4-methoxyphenylboronic acid 
• 105-53-3 diethyl malonate 
• 75907-21-0 2-[Hydroxy-(4-methoxy-phenyl)-methylene]-malonic acid diethyl ester 

Downstream Products

• 23982-31-2 7-hydroxy-4-(4-methoxyphenyl)-2H-chromen-2-one 
• 370582-94-8 7,8-dihydroxy-4-(4-methoxyphenyl)-2H-chromen-2-one 
• 75907-21-0 2-[Hydroxy-(4-methoxy-phenyl)-methylene]-malonic acid diethyl ester 
• 7394-23-2 p-Brom-benzolsulfonsaeure-<1-p-anisoyl-2,2-diaethoxycarbonyl-vinylester> 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant academic research and scientific papers

Efficient synthesis of 4-ethoxycarbonyl pyrazolin-5-one derivatives

Concise and efficient methods for the preparation of 3-substituted 4-ethoxycarbonylpyrazolin-5-ones are described. The synthetic strategies involve carbon-acylation in the presence of base, followed by ring cyclization with hydrazine or hydrazine monohydrochloride.

Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis

A series of 4H-chromen-4-one derivatives obtained by scaffold morphing of the benzofuran compound, TAM16, were tested for antitubercular activity. Compound 8d was active against drug-sensitive and multidrug-resistant tuberculosis. A preliminary druggability evaluation showed that compound 8d displayed favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability. An in vivo study indicated that compound 8d exhibited modest efficacy in an acute mouse model of TB after 3 weeks of treatment. Thus, 8d is a promising antituberculosis lead compound.

Pd-catalyzed carbonylation for the construction of tertiary and quaternary carbon centers with sp3 carbon partners

The first examples of a Pd-catalyzed carbonylation of aryl boronic acids with sp3 carbon partners are presented. Various boronic acids were shown to react with 1,3-diesters and 1,3-diketones to afford structurally unique carbonyl compounds. By

SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile

(Chemical Equation Presented) A recyclable, convenient, and efficient catalytic system for C-acylation of 1,3-dicarbonyl compounds and malononitrile with acid chlorides has been developed, giving moderate to excellent yields under mild conditions. This is the first catalytic example of such reactions. In addition, by applying this protocol as the key step, 3,5-disubstituted-1H- pyrazole-4-carboxylate can easily be synthesized in high yields in a one-pot procedure.

TRANSMISSION OF SUBSTITUENT EFFECTS IN PARA SUBSTITUTED BENZOYLMALONATE DERIVATIVES

Acidity constants and enol contents of ethyl benzoylmalonate and its para derivatives (CH3O, CH3, Cl, CN, NO2) were determined in 75 vol.percent ethanol-water solutions.Acidity constants of keto and enol forms were calculated and correlated with substituents constants ?p.IR spectra and enol contents were also determined in CCl4 solutions.