7596-12-5

Usage

Uses

Used in Pharmaceutical Industry:
(3-methyl-4-nitrophenyl)(phenyl)methanone is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex organic molecules, contributing to the development of new drugs and medicinal compounds.
Used in Dye Industry:
In the dye industry, (3-methyl-4-nitrophenyl)(phenyl)methanone is used as a precursor for the production of dyes, taking advantage of its aromatic structure and reactivity to create a range of colorants for various applications.
Used in Organic Compounds Synthesis:
(3-methyl-4-nitrophenyl)(phenyl)methanone is utilized as a building block in the synthesis of other organic compounds, leveraging its chemical properties to form a variety of products across different industries.
Safety Note:
It is important to handle (3-methyl-4-nitrophenyl)(phenyl)methanone with care, as it can be hazardous if not used properly due to its potential for causing skin and eye irritation. Proper safety measures should be taken during its use to minimize risks.

Upstream product

• 143064-49-7 1-(Ethoxy-phenyl-methyl)-1H-benzotriazole 
• 88-72-2 1-methyl-2-nitrobenzene 
• 654068-39-0 (2S,5R)-2-tert-butyl-5-(3-methyl-4-nitrophenyl)-5-phenyl-1,3-dioxolan-4-one 
• 81036-97-7 (2S,5S)-2-tert-butyl-5-phenyl-1,3-dioxolan-4-one 
• 446-33-3 5-Fluoro-2-nitrotoluene 
• 654068-46-9 (R)-3-methyl-4-nitrobenzilic acid 

Downstream Products

• 159390-17-7 4-amino-3-cyanobenzophenone 
• 130344-75-1 4-benzoyl-2-carbamoylaniline 
• 72106-42-4 5-benzoyl-2-nitrobenzonitrile 
• 130344-74-0 5-Benzoyl-2-nitro-benzamide 
• 130344-80-8 5-Benzoyl-2-nitro-benzoyl chloride 
• 114521-66-3 5-benzoyl-isoindoline-1,3-dione 
• 3886-01-9 4-benzoyl-phthalic acid-anhydride 
• 3885-88-9 4-benzoyl-phthalic acid 
• 13209-03-5 2-benzoylanthracene-9,10-dione 
• 3885-89-0 2,5-dibenzoyl-benzoic acid 
• 857008-53-8 4-benzoyl-2-methyl-benzonitrile 
• 857005-23-3 4-benzoyl-2-methyl-benzoic acid 
• 859968-67-5 1,4-dibenzoyl-2-methyl-benzene 
• 857537-59-8 2,4-dibenzoyl-benzoic acid 

Relevant academic research and scientific papers

Highly diastereoselective arylation of (S)-mandelic acid enolate: Enantioselective synthesis of substituted (R)-3-hydroxy-3-phenyloxindoles and (R)-benzylic acids and synthesis of nitrobenzophenones

An easy access to substituted (R)-3-hydroxy-3-phenyloxindoles, (R)-benzylic acids, and benzophenones is described. The reaction of the lithium enolate of the (2S,5S)-cis-1,3-dioxolan-4-one derived from optically active (S)-mandelic acid and pivalaldehyde with several o- and p-halonitrobenzenes proceeds readily to give the corresponding arylation products in good yields and diastereoselectivities. The reduction of the nitro group with Zn/HCl/EtOH in the o-nitro arylation products with concomitant intramolecular aminolysis of the dioxolanone moiety leads directly to enantiomerically pure (R)-3-hydroxy-3- phenyloxindoles. On the other hand the basic hydrolysis of the dioxolanone moiety in all the arylation products (ortho and para) leads to enantiomerically pure substituted (R)-benzylic acids. The oxidative decarboxylation of these latter with oxygen as terminal oxidant in the presence of pivalaldehyde and the Co(III)-Me2opba complex as catalyst gives substituted nitrobenzophenones.

Mandelic Acid as Synthetic Equivalent of Benzoyl Carbanion. Synthesis of Nitrobenzophenones

Nitrobenzophenones are prepared from a mandelic acid dioxolanone. The sequence starts with the aromatic nucleophilic substitution of the enolate of the dioxolanone onto p-fluoronitrobenzenes, followed by hydrolysis of the acetal moiety and oxidative decarboxylation of the resulting α-hydroxyacids. The whole sequence involves the use of mandelic acid as synthetic equivalent of the benzoyl carbanion.

Reactions of 1-(benzotriazol-1-yl)-1-phenoxyalkane and (benzotriazol-1- yl)ethoxyphenylmethane anions with nitroarenes: A new approach to alkyl and aryl p-nitroaryl ketones

p-Nitroaryl alkyl ketones and p-nitroaryl aryl ketones are prepared regioselectively by reactions of non-functionalized nitroarenes and benzotriazole stabilized carbanions.