7598-26-7

Basic information

• Product Name: 2-AMINO-3-NITRO-5-PICOLINE
• Synonyms: 2-AMINO-3-NITRO-5-PICOLINE;2-AMINO-5-METHYL-3-NITROPYRIDINE;6-AMINO-5-NITRO-3-PICOLINE;AMINO(2-)-3-NITRO-5-METHYLPYRIDINE;6-Amino-5-nitro-3-picoline, 98+%;5-Methyl-3-nitropyridin-2-amine;2-Pyridinamine, 5-methyl-3-nitro-;6-AMino-5-nitro-3-picoline, 98+% 5GR
• CAS NO: 7598-26-7
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• EINECS: -0
• Product Categories: compounds of pyridine;Pyridine series;Pyridine;Heterocyclic Compounds;Amines;Pyridines;Amino-pyridine series;amine | nitro-compound
• Mol File: 7598-26-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 189-193 °C
• Boiling Point: 318.9 °C at 760 mmHg
• Flash Point: 146.7 °C
• Appearance: Ochre/Crystalline Powder
• Density: 1.354 g/cm³
• Vapor Pressure: 0.00035mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.54±0.49(Predicted)
• CAS DataBase Reference: 2-AMINO-3-NITRO-5-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-NITRO-5-PICOLINE(7598-26-7)
• EPA Substance Registry System: 2-AMINO-3-NITRO-5-PICOLINE(7598-26-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-22
• Hazardous Substances Data: 7598-26-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H7N3O2/c1-4-2-5(9(10)11)6(7)8-3-4/h2-3H,1H3,(H2,7,8)

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 91752-76-0 3-aminomethacrylaldehyde 
• 71090-35-2 1,1-diamino-2-nitroethene 
• 7464-15-5 5-methyl-2-nitraminopyridine 

Downstream Products

• 3430-19-1 5-methylpyridin-3-amine 
• 23056-46-4 2-bromo-5-methyl-3-nitropyridine 
• 7463-59-4 3-methyl-5-nitro-pyridine-2,6-diyldiamine 
• 24638-29-7 2,3-diamino-5-methyl-pyridine 

Relevant articles and documents

HETEROARYL SULFONAMIDES AND CCR2

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor

Disclosed is a method of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma or hypoglycemia. The method comprises administering to an animal a compound of the formula: STR1 or a pharmaceutically acceptable salt thereof; wherein n is zero or 1; R 4, R 5, R 6 are independently hydrogen, nitro, amino, halo, haloalkyl, cyano, alkyl, cycloalkyl, alkenyl, alkynyl, azido, acylamino, alkylsulfonyl, aryl, substituted aryl, heteroaryl, alkoxy, trialkylsilyl-substituted alkoxy, aryloxy, substituted aryloxy, heteroaryloxy, a heterocyclic group, a heterocyclicoxy group, aralkoxy, or haloalkoxy; and R c and R d are defined in the specification. These compounds have high binding to the glycine site of the NMDA receptor.

SYNTHESES WITH AROMATIC NITRAMINES, VI SUBSTITUENT EFFECT IN THE PHOTOLYTIC REARRANGEMENT OF NITRAMINOPYRIDINES

All isomeric ring-substituted methyl-2-nitraminopyridines, both 3-nitro- and 5-nitro-2-nitraminopyridines, 5-chloro- and 3-carboxy-2-nitraminopyridines, as well as 3,5-dibromo-2-nitraminopyridine were photolyzed in methanol by irradiation with a low-pressure mercury lamp (253.7 nm).Preference was generally noted for the migration of the side-chain nitro group to the vicinal β-position. 3,5-Dibromo-2-nitraminopyridine gave both 2-amino-3,5-dibromopyridine and 3,5-dibromopyridine-2-one.The ratio of the preparative and quantum yields of the two products were 2.5 and 3.0, respectively.