75984-49-5Relevant articles and documents
Solventless lactam synthesis by intramolecular cyclizations of α-iminoester derivatives under microwave irradiation
Zradni, Fatima-Zohra,Hamelin, Jack,Derdour, Aicha
, p. 439 - 454 (2007/10/03)
We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoes
X=Y-ZH SYSTEMS AS POTENTIAL 1,3-DIPOLES. PART 17. SEQUENTIAL MICHAEL ADDITION-5-ENDO-TRIG CYCLISATION OF ARYLIDENE IMINES OF Α-AMINO ACID ESTERS
Grigg, Ronald,Kemp, James,Malone, John F.,Rajviroongit, Shuleewan,Tangthongkum, Anant
, p. 5361 - 5374 (2007/10/02)
Imines of α-amino acid esters undergo regiospecific Michael addition to methyl acrylate or acrylonitrile in good yield in benzene at 25 degC catalysed by benzyltrimethylammonium methoxide (BTAM).The Michael adducts cyclise to a mixture of two stereoisomer