76003-34-4

Upstream product

• 76003-29-7 4-(t-butyloxycarbonyl)piperazin-2-one 
• 100-52-7 benzaldehyde 
• 889958-14-9 tert-butyl 2-oxopiperazine-1-carboxylate 
• 75-36-5 acetyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

Enkaphalin derivatives

Novel analgesic and antipsychotic agents having the formula STR1 wherein Q is STR2 in which R1 is hydrogen, hydroxy or halogen and R4 is hydrogen or, R1 and R4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sulfinyl or sulfonyl, or Z and X, taken together, are methylidenyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R5 is hydrogen or halogen, and R2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group STR3 or the group STR4 wherein R3 is hydroxy, amino, alkylamino or dialkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantiomers and pharmaceutically acceptable salts thereof.

Alkylation of protected piperazinone dianions

A new method for the preparation of substituted piperazinones via alkylation of t-boc-piperazinone is presented.