76049-61-1Relevant academic research and scientific papers
Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators
Wu, Yong-Jin,Zhang, Yunhui,Toyn, Jeremy H.,Macor, John E.,Thompson, Lorin A.
, p. 1554 - 1557 (2016/07/27)
This Letter describes an efficient ring-closing metathesis approach to 2-chloro-4-amino-pyrimido[4,5-c]azepines and 2-chloro-4-amino-pyrimido[4,5-c]oxepines. These chlorides were applied to the synthesis of several potent γ-secretase modulators (GSMs).
3H-2-Benzazepines
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, (2008/06/13)
There is presented 3H-2-benzazepines and 4,5-dihydro-3H-2-benzazepines of the formula STR1 wherein X is hydrogen, chloro or bromo, Y is hydrogen, fluoro or chloro with the proviso that X and Y cannot both be hydrogen and R1 is selected from the
N-oxides of 5-oxo-1-phenyl-2-benzazepines
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, (2008/06/13)
Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ
2-Benzazepines. 1. Synthesis of 2-Benzazepin-4-ones and -5-ones via 2-Acetylenic Benzophenones
Trybulski, Eugene J.,Reeder, Earl,Blount, John F.,Walser, Armin,Fryer, R. Ian
, p. 2441 - 2447 (2007/10/02)
The preparation of 1-phenyl-2-benzazepin-4-ones and -5-ones is discussed.The palladium-catalyzed coupling of an iodobenzophenone to a monosubstituted acetylene assembles the necessary atoms required for the benzazepine ring.Transformation of the acetylene
Intermediates in the production of 2-benzazepines
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, (2008/06/13)
Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ
