81078-22-0Relevant academic research and scientific papers
Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators
Wu, Yong-Jin,Zhang, Yunhui,Toyn, Jeremy H.,Macor, John E.,Thompson, Lorin A.
, p. 1554 - 1557 (2016/07/27)
This Letter describes an efficient ring-closing metathesis approach to 2-chloro-4-amino-pyrimido[4,5-c]azepines and 2-chloro-4-amino-pyrimido[4,5-c]oxepines. These chlorides were applied to the synthesis of several potent γ-secretase modulators (GSMs).
2-Benzazepines. 9. Synthesis and Chemistry of 3H-2-Benzazepine and Pyrimidobenzazepine Derivatives
Trybulski, E.J.,Fryer, R.I.,Reeder, E.,Vitone, S.,Todaro, L.
, p. 2191 - 2202 (2007/10/02)
The synthesis of 8-chloro-1-phenyl-3H-2-benzazepine analogues 6a-c and their dihydro derivatives 9a-c from the corresponding alkynes 1a-c is discussed.The bromination followed by dehydrobromination of 6a-c led to the formation of the corresponding 5-bromo
