76049-52-0

Upstream product

• 7223-50-9 N-propargylphthalimide 
• 76049-48-4 5-chloro-2-iodobenzophenone 
• 109-89-7 diethylamine 
• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 76049-61-1 3-amino-1-[4-chloro-2-benzoylphenyl]propyne 
• 81078-12-8 1-(4-chloro-2-benzoylphenyl)-3-phthalimidopropane 
• 81078-16-2 1-<4-chloro-2-benzoylphenyl>-3-phthalimidopropene 
• 76049-60-0 1-[4-chloro-2-benzoylphenyl]-3-phthalimidopropan-1-one 
• 83948-80-5 4-[4-chloro-2-benzoylphenyl]-5-[N-phthalimidomethyl]-2H-1,2,3-triazole 
• 78131-52-9 8-chloro-6-phenyl-2H,4H-<1,2,3>triazolo<4,5-d><2>benzazepine 
• 81078-22-0 8-chloro-1-phenyl-3H-2-benzazepine 
• 81078-14-0 8-chloro-4,5-dihydro-1-phenyl-3H-2-benzazepine hydrochloride 
• 78367-96-1 2-<<2-amino-4-(2-benzoyl-4-chlorophenyl)-5-thiazolyl>methyl>-1H-isoindole-1,3(2H)-dione 
• 78379-98-3 2-<<4-(2-benzoyl-4-chlorophenyl)-2-methyl-5-thiazolyl>methyl>-1H-isoindole-1,3(2H)-dione 
• 78367-92-7 2-<3-(2-benzoyl-4-chlorophenyl)-2-bromo-3-oxopropyl>-1H-isoindole-1,3(2H)-dione 
• 78368-02-2 8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-amine 

Relevant academic research and scientific papers

Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators

This Letter describes an efficient ring-closing metathesis approach to 2-chloro-4-amino-pyrimido[4,5-c]azepines and 2-chloro-4-amino-pyrimido[4,5-c]oxepines. These chlorides were applied to the synthesis of several potent γ-secretase modulators (GSMs).

3H-2-Benzazepines

There is presented 3H-2-benzazepines and 4,5-dihydro-3H-2-benzazepines of the formula STR1 wherein X is hydrogen, chloro or bromo, Y is hydrogen, fluoro or chloro with the proviso that X and Y cannot both be hydrogen and R1 is selected from the

Pyrimido[4,5-d][2]benzazepines

There is presented a compound of the formula STR1 wherein R1 is selected from the group consisting of hydrogen, lower alkyl, chloro, bromo, alkoxy, hydroxy, lower alkyl substituted thio and NR4 R5 wherein R4 and

N-oxides of 5-oxo-1-phenyl-2-benzazepines

Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ

Intermediates in the production of 2-benzazepines

Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ

2-Benzazepines. 1. Synthesis of 2-Benzazepin-4-ones and -5-ones via 2-Acetylenic Benzophenones

The preparation of 1-phenyl-2-benzazepin-4-ones and -5-ones is discussed.The palladium-catalyzed coupling of an iodobenzophenone to a monosubstituted acetylene assembles the necessary atoms required for the benzazepine ring.Transformation of the acetylene

Triazolobenzazepines and processes for their production

There is presented triazolobenzazepines of the formula STR1 wherein R1 is hydrogen or lower alkyl and X and Y are hydrogen or halogen and the pharmaceutically acceptable salts thereof. Also disclosed are novel processes and intermediates leadin