76154-00-2

Basic information

• Product Name: Propanedioic acid, ethyl(phenylmethyl)-, diethyl ester
• CAS NO: 76154-00-2
• Molecular Formula: C16H22O4
• Molecular Weight: 278.348
• Mol File: 76154-00-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, ethyl(phenylmethyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, ethyl(phenylmethyl)-, diethyl ester(76154-00-2)
• EPA Substance Registry System: Propanedioic acid, ethyl(phenylmethyl)-, diethyl ester(76154-00-2)

Safety Data

• Hazardous Substances Data: 76154-00-2(Hazardous Substances Data)

Upstream product

• 56524-87-9 1-benzyl-2,4,6-triphenylpyridinium cation 
• 76153-99-6 anion of diethyl ethylmalonate 
• 100-44-7 benzyl chloride 
• 133-13-1 ethyl diethyl malonate 
• 66310-10-9 N-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate 
• 75-03-6 ethyl iodide 
• 607-81-8 diethyl 2-benzylmalonate 
• 100-51-6 benzyl alcohol 
• 104856-46-4 benzyl 2,3,4,5,6-pentafluorobenzoate 
• 105-53-3 diethyl malonate 
• 100-39-0 benzyl bromide 
• 100-46-9 benzylamine 
• 74-96-4 ethyl bromide 

Downstream Products

• 36226-64-9 5-benzyl-5-ethyl-pyrimidine-2,4,6-trione 
• 162169-82-6 3-((α[R]-cyclopropyl)-meta-(4-cyanophenylsulfonylamino)benzyl)-6-(α[S]-ethylphenethyl)-4-hydroxy-2H-pyran-2-one 
• 162174-91-6 (S) 2,2-dimethyl-6-(α-ethylphenethyl)-4H-1,3-dioxin-4-one 
• 159563-72-1 (R) 2,2-dimethyl-6-(α-ethylphenethyl)-4H-1,3-dioxin-4-one 
• 159563-71-0 3-([S]-α-ethylbenzyl)-4-hydroxy-6-([R]-α-ethylphenethyl)-2H-pyran-2-one 
• 170899-02-2 (2S)-2-Benzyl-1-butanol 
• 56640-48-3 (R)-2-(phenylmethyl)butanol 
• 56640-48-3 2-benzyl butanol 

Relevant articles and documents

Synthesis and olfactory evaluation of optically active β-alkyl substituted γ-lactones and whiskey lactone analogues

Optically active β-alkyl substituted γ-lactones and whiskey lactone analogues were synthesized, and the odor properties were evaluated. During the preparation of the chiral intermediates, we found good reaction conditions for the highly enantioselective esterification of 3-arylmethyl-2-methyl-1-propanols to kinetically resolve them. The results of the olfactory evaluations of the synthesized lactones revealed that the alkyl groups on the γ-lactone rings played an important role for the odor profiles.

Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases

Certain 2H-pyran-2-ones are useful for treating benign prostatic hypertrophy or hyperplasia, prostatic cancer, alopecia, hirsutism, acne vulgaris and seborrhea.

CHEMOENZYMATIC SYNTHESIS OF THE ENANTIOMERS OF IOPANOIC ACID

The two enantiomers of Iopanoic acid 1 were prepared in enantiomeric excess higher than 90percent by enzyme-catalyzed hydrolysis of precursors (+/-)-2a and (+/-)-3a, followed by standard chemical transformations.Among the tested enzymes, chymotrypsin and Lipase PS proved to be the most selective catalysts.The stereochemical outcome of the lipase-catalyzed hydrolyses of esters (+/-)-2a-d is strictly dependent upon both the size of the alkyl group attached to the chiral center and the substituent in the aromatic ring.The enantioselectivity of the reactions was evaluated by chiral HPLC and the configurations of the new products were assigned by chemical correlations.