76167-46-9Relevant academic research and scientific papers
A new biarylphosphine ligand for the Pd-catalyzed synthesis of diaryl ethers under mild conditions
Salvi, Luca,Davis, Nicole R.,Ali, Siraj Z.,Buchwald, Stephen L.
supporting information; experimental part, p. 170 - 173 (2012/03/08)
A new bulky biarylphosphine ligand (L8) has been developed that allows the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions than previously possible. A direct correlation between the size of the ligand substituents in the 2′, 4′, and 6′ positions of the nonphosphine containing ring and the reactivity of the derived catalyst system was observed. Specifically, the rate of coupling increased with the size of these substituents.
Pyridine derivatives and their uses as fungicides and insecticides
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, (2008/06/13)
Acrylic acid derivatives having the formula (I): STR1 and stereoisomers thereof, wherein W is R1 O2 C--C=CH--ZR2, R1 and R2 are alkyl or fluoroalkyl groups, and Z is oxygen or sulphur; A, B, D and E are hydrogen, halogen, hydroxy or optionally substituted alkyl, alkoxy, aralkyl, arylalkoxy, alkenyl, alkynyl, aryl, aryloxy, arylthio, heteroaryloxy, heteroarylthio, acyloxy, amino, arylazo or acylamino, nitro, cyano, --CO2 R3, --CONR3 R4, --COR3, --CR3 =NR4, --N=CR3 R4 or --S(O)n R3 groups; any two of the groups A, B, D and E, when they are in adjacent positions on the ring, optionally join to form a fused ring, n is 0, 1 or 2; and R3 and R4 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl or optionally substituted aryl or aralkyl; and metal complexes thereof. These compounds are useful as fungicides, insecticides, nematicides or plant growth regulators.
Pyrylium Salts as Photosensitizers in Homogeneous and Heterogeneous Electron-Transfer Catalysis. - A Comparison with Cyano Arenes
Mattay, Jochen,Vondenhof, Martin,Denig, Richard
, p. 951 - 958 (2007/10/02)
Two new triphenylpyrylium salts, both being fixed to a polymeric backbone, have been synthesized.They are sensitizers for photochemically induced electron-transfer reactions, offering the possibility of heterogeneous charge transfer.Their usability in electron-transfer-catalyzed dimerizations and mixed cycloadditions of 1,3-cyclohexadiene and phenyl vinyl ether has been tested in comparison to other common photosensitizers such as 9,10-dicyanoanthracene and 1,4-dicyanonaphthalene.In addition, 2,4,6-triphenylpyrylium tetrafluoroborate was shown to operate as an efficient sensitizer for the dimerization and the photooxygenation of 1,1-diphenylethene.Diverse selectivities in the product formation indicate different mechanisms and are discussed in view of earlier results reported in the literature. - Key Words: Electron-transfer photocatalysis / Electron transfer, photoinduced / Photooxygenation / Pyrylium salts, polymeric / Radical cation cycloadditions
Cognition-Activating Properties of 3-(Aryloxy)pyridines
Butler, Donald E.,Poschel, B. P. H.,Marriott, John G.
, p. 346 - 350 (2007/10/02)
A series of 3-(aryloxy)pyridines was found to possess activity in enhancing retention for passive avoidance learning in mice.This test was used to select compounds with potential therapeutic properties for the treatment of cognitive disorders.Reference drugs that gave positive results in this procedure included d-amphetamine, magnesium pemoline, methyl phenidate, picrotoxin, phenytoin, and ethosuximide.All active compounds gave inverted U-shaped doseresponse curves.The most active compounds of the 3-(aryloxy)pyridines included 3-phenoxypyridine (1), 3-(2-fluorophenoxy)pyridine (2), 3-(4-fluorophenoxy)pyridine (4), 3,3'-oxybis(pyridine) (23), and 3,3'-oxybis(pyridine) 1-oxide (24). 3-Phenoxypyridine (1) was clearly superior to all of the analogues tested in terms of the level of retention, grammometric potency, and the breadth of its inverted U-shaped dose-response curve.It was given the designation of CI-844 and after a detailed study of its pharmacological profile was submitted for preclinical toxicology.
