7623-13-4

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dichloropropionyl chloride is utilized as a building block for the development of new drugs, playing a vital role in the synthesis of pharmaceuticals due to its reactivity and ability to form acyl chloride groups.
Used in Agrochemical Production:
2,3-DICHLOROPROPIONYL CHLORIDE also serves as an intermediate in the production of insecticides and herbicides, contributing to the development of effective agricultural chemicals for pest and weed control.
Safety Considerations:
It is important to handle 2,3-dichloropropionyl chloride with caution due to its potential to cause irritation to the skin, eyes, and respiratory system. Moreover, its high flammability necessitates proper storage and handling in accordance with established safety protocols.

InChI:InChI=1/C3H3Cl3O/c4-1-2(5)3(6)7/h2H,1H2

Upstream product

• 2567-14-8 3,3-dichloroallyl chloride 
• 2233-00-3 3,3,3-trichloro-1-propene 
• 50-00-0 formaldehyd 
• 7446-70-0 aluminium trichloride 
• 79-01-6 Trichloroethylene 
• 110-88-3 1,3,5-Trioxan 
• 473-81-4 glyceric acid 
• 79-00-5 1,1,2-trichloroethane 
• 107-94-8 chloropropionic acid 
• 565-64-0 2,3-dichloropropanoic acid 

Downstream Products

• 3674-09-7 methyl 2,3-dichloropropionate 
• 76258-15-6 (Ξ)-2,3-dichloro-propionic acid-[(1RS,2RS)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylamide] 
• 21369-76-6 α-chloroacryloyl chloride 
• 6628-21-3 ethyl 2,3-dichloropropionate 
• 17839-22-4 2.3-Dichlor-propionsaeure-anilid 
• 7078-85-5 2.3-Dichlor-propionsaeure-<3-chlor-anilid> 
• 565-64-0 2,3-dichloropropanoic acid 
• 19433-84-2 α,β-dichloropropionamide 
• 141936-51-8 2,3-Dichloro-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 141936-53-0 2,3-Dichloro-propionic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 141936-52-9 2,3-Dichloro-propionic acid (1S,2R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 17209-22-2 2,3-dichloro-N-(4-chlorophenyl)propanamide 
• 306996-54-3 2-(2,3-dichloropropionylamino)-benzamide 

Relevant academic research and scientific papers

Preparation and preservation method of 2-chloro-N-n-octyl acrylamide

The invention discloses a preparation and preservation method of 2-chloro-N-n-octyl acrylamide. The 2-chloro-N-n-octyl acrylamide is an impurity concomitant with production of DCOIT, and the prepared high-purity 2-chloro-N-n-octyl acrylamide has a role in guiding production of the DCOIT. The method comprises that 2,3-methyl dichloropropionate is subjected to three-step reaction of hydrolysis, acylating chlorination and amination dehydrochlorination to obtain the final product, and an antioxidant is added in purification and preservation processes and can prevent polymerization metamorphism of the product.

Reaction of (α-halogenoalkyl)thiiranes with nucleophilic reagents I. Reaction with morpholine

By means of deuterated compounds it was established that (chloromethyl)thiirane reacts with morpholine by a mechanism involving initial opening of the thiirane ring followed by recyclization.In the case of (bromomethyl)thiirane direct substitution of the bromine begins to compete with this mechanism. 2-Methyl-2-(chloromethyl)thiirane, 2,2-dimethyl-3-(chloromethyl)thiirane, and the diastereomeric (1-chloroethyl)thiiranes were synthesized, and their reactivity toward morpholine was studied.

α-FLUOROACRYLIC ACID CHLORANHYDRIDE

Kinetic studies were carried out on the reaction of 2-fluoro-3-chloropropanoic acid and other halo- and methoxy-substituted propanoic acids with thionyl chloride at 50-110 deg C.The catalytic dehydro-chlorination of 2-fluoro-3-chloropropanoic acid chloranhydride by tertiary amines and their salts was investigated.Dimethylaniline chlorohydrate was shown to be an effective catalyst, providing maximum dehydrochlorination at a concentration of 20percent.A mechanism for the reaction was proposed.