76244-62-7Relevant articles and documents
Anti-convulsant potential of quinazolinones
Patel, Harun M.,Noolvi, Malleshappa N.,Shirkhedkar, Atul A.,Kulkarni, Abhijeet D.,Pardeshi, Chandrakantsing V.,Surana, Sanjay J.
, p. 44435 - 44455 (2016/06/09)
A series of novel quinazoline derivatives were synthesized, virtually screened through different filters and evaluated for their anticonvulsant activity against electrically and chemically induced seizures, compared with that of the standard drugs methaqualone and sodium valproate. Compound 48, 3-(2-aminophenyl)-7-chloro-2-phenylquinazolin-4(3H)-one, was found to be the most potent compound of the series accompanied by relatively low neurotoxicity and low toxicity in the median lethal dose test as compared with the reference drugs. The obtained results showed that compounds 12, 48, 49 and 50 could be useful templates for future design, optimization, and investigation to construct more active analogs.
Synthesis of Some New 2-Aryl-3-Hetaryl-4(3H) Quinazolones
Dash, B.,Dora, E. K.,Panda, C. S.
, p. 835 - 836 (2007/10/02)
2-Aryl (alkyl)-benzoxazin-4-ones (I, R = CH3, C6H5, C6H5CH2, p-NO2C6H4) are condensed with 2-amino hetaryls (pyridyl, pyrimidyl, thiazolyl), 1 and 2-amino anthraquinones, p-amino acetophenone and 1,2-diamines like ethylene diamine and o-phenylene diamine.The products are obtained in excellent yields and are characterised by infrared and elemental analysis.
