76350-04-4

Basic information

• Product Name: 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride
• Synonyms: Iopromide P-1;5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride;3- methoxy acetamide -5- (2,3- dihydroxyl procarbamide) -2,4,6- triiodobenzoyl chloride;Benzoyl chloride, 3-[[(2,3-dihydroxypropyl)amino]carbonyl]-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-
• CAS NO: 76350-04-4
• Molecular Formula: C₁₄H₁₄ClI₃N₂O₆
• Molecular Weight: 722.44
• Mol File: 76350-04-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride(76350-04-4)
• EPA Substance Registry System: 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride(76350-04-4)

Safety Data

• Hazardous Substances Data: 76350-04-4(Hazardous Substances Data)

Usage

General Description

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride is a complex chemical compound with a long name. It consists of a 2,4,6-triiodoisophthalic acid core, which is attached to an amino group, acetyl group, and a 2,3-dihydroxypropyl group. The presence of three iodine atoms makes it highly radiodense, making it useful for imaging studies such as CT scans. The compound is also water-soluble, making it suitable for use as a contrast agent. It is often used in medical imaging procedures to enhance the visibility of certain organs and tissues in the body. Additionally, the amide chloride structure gives it stability and compatibility with biological systems, making it safe for use in medical applications.

Upstream product

• 76350-03-3 5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride 
• 616-30-8 3-Amino-1,2-propanediol 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 

Downstream Products

• 150928-21-5 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride 
• 73334-07-3 iopromide 

Relevant articles and documents

Method for preparing iopromide intermediate

The invention discloses a method for preparing an iopromide intermediate. The method comprises the following steps: 1) taking a compound I5-amino-2,4,6-triiodo-1,3-benzoyl chloride and methoxyacetyl chloride as raw materials, triethylamine as an acidifyin

A METHOD FOR PREPARING AN INTERMEDIATE OF IOPROMIDE

The present invention relates to a method for preparing an intermediate of iopromide, and more particularly, to a method for preparing an intermediate of iopromide, in which 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid dichloride is produced using 1,4-dioxane as a reaction solvent, and then reacted with 3-amino-1,2-propanediol using a solvent mixture of 1,4-dioxane or tetrahydrofuran (THF) and isopropanol as a reaction solvent to obtain the intermediate of iopromide with a faster reaction time, a smaller amount of solvent, and a higher yield.

NOVEL PROCESS FOR PREPARATION OF IOPROMIDE

The present invention relates to a novel process for preparing iopromide which is used as a contrast agent for X-ray, wherein 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride of formula (19) and 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide of formula (20) are introduced as intermediates, by which a bismer by-product generated during the preparation process can be removed even without an additional removal procedure and thus iopromide with high purity can be prepared in high yield.