76350-04-4

Usage

Uses

Used in Medical Imaging:
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride is used as a contrast agent for enhancing the visibility of organs and tissues in the body during imaging studies such as CT scans. Its high radiodensity allows for better differentiation between various structures within the body, improving diagnostic accuracy.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride is used as a building block for the development of new drugs. Its unique chemical properties and compatibility with biological systems make it a valuable component in the synthesis of pharmaceutical compounds with potential therapeutic applications.
Used in Research and Development:
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride is utilized in research and development for the study of its chemical properties and potential applications in various fields. Its unique structure and properties make it an interesting subject for scientific investigation, potentially leading to new discoveries and innovations.
Used in Diagnostic Tools:
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride is employed in the development of diagnostic tools that rely on imaging techniques. Its high radiodensity and water-solubility make it suitable for use in contrast agents that can improve the accuracy and reliability of diagnostic procedures.
Used in Biomedical Applications:
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride is used in biomedical applications for its potential to interact with biological systems. Its stability and compatibility with biological molecules make it a promising candidate for use in the development of new therapies and diagnostic methods.

Upstream product

• 76350-03-3 5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride 
• 616-30-8 3-Amino-1,2-propanediol 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 

Downstream Products

• 150928-21-5 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride 
• 73334-07-3 iopromide 

Relevant academic research and scientific papers

Method for preparing iopromide intermediate

The invention discloses a method for preparing an iopromide intermediate. The method comprises the following steps: 1) taking a compound I5-amino-2,4,6-triiodo-1,3-benzoyl chloride and methoxyacetyl chloride as raw materials, triethylamine as an acidifyin

The new method of preparing [...] (by machine translation)

The invention relates to a preparation method of iopromide. 5-methoxylacetamido-2,4,6-triiodo m-phthalic acid[(2-oxo-1,3-dioxolame-4-yl)methyl]amido chloride (Formula V) and 5-methoxylacetamido-2,4,6-triiodo m-phthalic acid{[(2-oxo-1,3-dioxolame-4-yl)methyl]-(2,3-dyhydroxyl-N-methyl propyl)}diamide (Formula VI) are introduced to be used as intermediates. Even if there is no additional purification step, a bismer by-product generated during the reaction also can be removed by introduction of the intermediates and high-purity iopromide can be prepared at high yield.

A METHOD FOR PREPARING AN INTERMEDIATE OF IOPROMIDE

The present invention relates to a method for preparing an intermediate of iopromide, and more particularly, to a method for preparing an intermediate of iopromide, in which 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid dichloride is produced using 1,4-dioxane as a reaction solvent, and then reacted with 3-amino-1,2-propanediol using a solvent mixture of 1,4-dioxane or tetrahydrofuran (THF) and isopropanol as a reaction solvent to obtain the intermediate of iopromide with a faster reaction time, a smaller amount of solvent, and a higher yield.

NOVEL PROCESS FOR PREPARATION OF IOPROMIDE

The present invention relates to a novel process for preparing iopromide which is used as a contrast agent for X-ray, wherein 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride of formula (19) and 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide of formula (20) are introduced as intermediates, by which a bismer by-product generated during the preparation process can be removed even without an additional removal procedure and thus iopromide with high purity can be prepared in high yield.

NOVEL PROCESS FOR PREPARATION OF IOPROMIDE

The present invention relates to a novel process for preparing iopromide which is used as a contrast agent for X-ray, wherein 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride of formula (19) and 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide of formula (20) are introduced as intermediates, by which a bismer by-product generated during the preparation process can be removed even without an additional removal procedure and thus iopromide with high purity can be prepared in high yield.