76352-71-1Relevant academic research and scientific papers
NEW METHOD FOR GENERATION OF THIOCARBONYL YLIDES FROM BIS(TRIMETHYLSILYLMETHYL)SULFOXIDES AND THEIR APPLICATION TO CYCLOADDITIONS
Aono, Masaaki,Terao, Yoshiyasu,Achiwa, Kazuo
, p. 249 - 260 (2007/10/02)
Thiocarbonyl ylides were generated by heating of bis(trimethylsilylmethyl)sulfoxides.Cycloadditions of the ylides in the presence of dipolarophiles proceeded smoothly to give di- or tetrahydrothiophenes.
CHEMOENZYMATIC SYNTHESIS OF THE ENANTIOMERS OF IOPANOIC ACID
Colombo, M.,Amici, M. De,Micheli, C. De,Pitre, D.,Carrea, G.,Riva, S.
, p. 1021 - 1030 (2007/10/02)
The two enantiomers of Iopanoic acid 1 were prepared in enantiomeric excess higher than 90percent by enzyme-catalyzed hydrolysis of precursors (+/-)-2a and (+/-)-3a, followed by standard chemical transformations.Among the tested enzymes, chymotrypsin and Lipase PS proved to be the most selective catalysts.The stereochemical outcome of the lipase-catalyzed hydrolyses of esters (+/-)-2a-d is strictly dependent upon both the size of the alkyl group attached to the chiral center and the substituent in the aromatic ring.The enantioselectivity of the reactions was evaluated by chiral HPLC and the configurations of the new products were assigned by chemical correlations.
Synthesis of 3-Phenoxybenzyl 3-Alkyl-3-phenyl-/p-substituted phenyl and 3-Phenoxybenzyl 2-Alkyl-3-phenyl-/p-substituted phenylpropionates
Kelkar, S. V.,Joshi, G. S.,Kulkarni, G. H.,Mitra, R. B.
, p. 68 - 70 (2007/10/02)
Some 3-phenoxybenzyl 3-alkyl-3-phenyl-/p-substituted phenylpropionates (VII, XI, XV, XIX, XXIII, XXVII) which resemble structurally the 1,2-secopyrethroids, have been prepared employing simple reactions like alkylation, decarbethoxylation and transesterification.The synthesis of 3-phenoxybenzyl 2-alkyl-3-phenyl-/p-substituted phenyl-propionates (XXXI, XXXII, XXXIII, and XXXVI) bearing close structural resemblance to 2,3-secopyrethroids has also been described.
