76385-35-8Relevant academic research and scientific papers
MACROCYCLIC FLU ENDONUCLEASE INHIBITORS
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Page/Page column 44; 45, (2020/05/19)
The present invention relates to macrocyclic pyridotriazine derivatives of formula (I) and the pharmaceutically acceptable salts, solvates or or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae famiIy. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.
Cp*Co(III)-Catalyzed γ-Selective C-H Allylation/Hydroamination Cascade for the Synthesis of Dihydroisoquinolines
Choi, Suh Young,Kim, Hyeon Dae,Park, Jong-Un,Park, Sun-A,Kim, Ju Hyun
supporting information, p. 10038 - 10042 (2019/12/24)
A Cp*Co(III)-catalyzed γ-selective C-H allylation/hydroamination cascade toward the synthesis of 3,4-dihydroisoquinolines (DHIQs) has been successfully developed, starting from NH ketimines and allyl carbonates. Notably, highly efficient and γ-selective C-H allylations were accomplished using γ-substituted allyl reagents, thus overcoming the issues of poor α/γselectivity and low reactivity of previous transition metal-catalyzed C-H allylations. The stereochemistry of allyl carbonates was a crucial factor, and synthesis of the DHIQs was achieved using (Z)-allyl carbonates.
Manganese-Catalyzed Aromatic C-H Allylation of Ketones
Ali, Shaukat,Huo, Jiaqi,Wang, Congyang
supporting information, p. 6961 - 6965 (2019/09/30)
Manganese-catalyzed aromatic C-H allylation of ketones is reported. The reaction proceeded in a monoselective allylation manner to provide various ortho C-H allylated ketones in high yields. With challenging allylic electrophiles bearing substituents at t
Weinreb Amide Directed Versatile C?H Bond Functionalization under (η5-Pentamethylcyclopentadienyl)cobalt(III) Catalysis
Kawai, Kentaro,Bunno, Youka,Yoshino, Tatsuhiko,Matsunaga, Shigeki
supporting information, p. 10231 - 10237 (2018/07/29)
The (η5-pentamethylcyclopentadienyl)cobalt(III) (Cp*CoIII)-catalyzed C?H bond functionalization of aromatic, heteroaromatic, and α,β-unsaturated Weinreb amides was explored. C?H allylation reactions with the use of allyl carbonate and a perfluoroalkene, oxidative alkenylation reactions with the use of ethyl acrylate, iodination reactions with the use of N-iodosuccinimide, and amidation reactions with the use of dioxazolones were catalyzed by Cp*Co(CO)I2 in the presence of a cationic Ag salt and AgOAc to afford various synthetically useful building blocks. Mechanistic studies of the C?H allylation disclosed that the C?H activation step was rate determining and virtually irreversible.
Weakly Coordinating, Ketone-Directed Cp?Co(III)-Catalyzed C-H Allylation on Arenes and Indoles
Sk, Md Raja,Bera, Sourav Sekhar,Maji, Modhu Sudan
supporting information, p. 134 - 137 (2018/01/17)
Weakly coordinating, ketone-directed, regioselective monoallylation of arenes and indoles is reported using a stable and cost-effective high-valent cobalt(III)-catalyst to access several important molecular building blocks. The allylation proceeds smoothl
Sterically hindered lithium dialkylcuprates for the generation of highly functionalized mixed cuprates through a halogen-copper exchange
Piazza, Claudia,Knochel, Paul
, p. 3263 - 3265 (2007/10/03)
Even aldehyde and ketone functions are tolerated in mixed organocuprates prepared by copper-halogen exchange using (Me3CCH2)2CuLi (Neopent2CuLi) or (PhMe2CCH2)2CuLi (Neophyl2CuLi). The steric hindrance of the neopentyl and neophyl groups is essential to ensure the chemoselectivity of the reaction (see scheme), and therefore allows a general preparation of polyfunctionalized organocuprates.
Titanocene-catalyzed cyclocarbonylation of o-allyl aryl ketones to γ- butyrolactones
Kablaoui, Natasha M.,Hicks, Frederick A.,Buchwald, Stephen L.
, p. 4424 - 4431 (2007/10/03)
A method for the transformation of o-allyl aryl ketones to γ- butyrolactones using a catalytic amount of Cp2Ti(PMe3)2 or Cp2Ti(CO)2 iS described. This catalytic 'hetero Pauson-Khand'-type process proc
RADIKALISCHE REAKTIONSWEGE BEI THERMISCH INDUZIERTEN UMSETZUNGEN VON ZIRCONOCENKOMPLEXEN
Erker, G.,Rosenfeldt, F.
, p. 1285 - 1292 (2007/10/02)
The formation of products 2, 3 and 4(a-l) from both the reaction of εta2-bezophenone zirconocene 1 with alkyl halides and the thermolysis of the α-(Cp2ZrCl)-substituted benzhydrylmethylether 9, the latter proceeding with anchimeric assistance of the metal, can be understood assuming a stepwise reaction path through radical intermediates.The proposed intermediate transition-metal benzophenone ketyl 12 exhibits a reaction pattern differing from analogous main-group-metal ketyls.
REVERSAL OF THE BENZOPHENONE REACTIVITY UPON η2 -COMPLEXATION TO BIS( η5 -CYCLOPENTADIENYL)ZIRCONIUM
Rosenfeldt, Frank,Erker, Gerhard
, p. 1637 - 1640 (2007/10/02)
Reversal of the carbonyl activity of benzophenone, serving as electron donor in single-electron transfer processes and acting as a proton acceptor through the 'carbonyl'carbon atom, is observed upon η2 -complexation to zirconocene.
