76385-55-2

Upstream product

• 3182-93-2 (L)-phenylalanine ethyl ester hydrochloride 
• 79-04-9 chloroacetyl chloride 
• 3081-24-1 H-Phe-OEt 

Downstream Products

• 1367887-21-5 C₁₄₀H₁₇₂N₄O₂₀ 
• 76385-72-3 (S)-3-Phenyl-2-(2-phosphono-acetylamino)-propionic acid ethyl ester 
• 952428-99-8 1,4,7-tris[(S)-{(1-ethoxycarbonyl-2-phenyl)ethyl}-carbamoylmethyl]-1,4,7,10-tetraazacyclododecane 
• 76385-62-1 (S)-ethyl 2-(2-(diethoxyphosphoryl)acetamido)-3-phenylpropanoate 

Relevant academic research and scientific papers

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

The heterotrimeric influenza virus polymerase performs replication and transcription of viral RNA in the nucleus of infected cells. Transcription by "cap-snatching" requires that host-cell pre-mRNAs are bound via their 5′ cap to the PB2 subunit. Thus, the PB2 cap-binding site is potentially a good target for new antiviral drugs that will directly inhibit viral replication. Docking studies using the structure of the PB2 cap-binding domain suggested that 7-alkylguanine derivatives substituted at position N-9 and N-2 could be good candidates. Four series of 7,9-di- and 2,7,9-trialkyl guanine derivatives were synthesized and evaluated by an AlphaScreen assay in competition with a biotinylated cap analogue. Three synthesized compounds display potent in vitro activity with IC50 values lower than 10 μM. High-resolution X-ray structures of three inhibitors in complex with the H5N1 PB2 cap-binding domain confirmed the binding mode and provide detailed information for further compound optimization.

Synthesis of L-phenylalanine ester derivatives of p-tert-butylcalix[8]arene

Synthetic routes were developed to link L-phenylalanine ester at the lower rim of p-tert-butylcalix[8]arene. Amide-type halides (2a-c) were synthesized by chloroacetic chloride and L-phenylalanine ester hydrochloride (1a-c), then reacted with p-tert-butyl

Towards aqueous chiral heptadentate lanthanide complexes as selective shift and relaxation agents for MRS

Magnetic resonance spectroscopy (MRS) is of prime importance in diagnostics and offers a means of analyzing, in vivo, the chemical content of living tissue, as a non-invasive alternative to biopsy. Several heptadentate, lanthanide complexes have been synt

Efficient coupling of amino acid derivatives to rigid organic scaffolds: Model syntheses for de novo proteins

We describe the coupling of amino acid derivatives to four different rigid organic macrocycles. The couplings were achieved in high yields, which augurs well for the coupling of polypeptides to the rigid macrocycles to create a new family of de novo prote

Inhibitors of Pyrimidine Biosynthesis. Part 1. Synthesis of Potential Transition-state Analogues of Aspartate Transcarbamylase

A systematic variation of the structure of a transition-state analogue of aspartate transcarbamylase has been carried out.A new, and general, synthesis of these analogues, starting from the appropriate amino-acid is described.