76412-58-3Relevant articles and documents
NiH-Catalyzed Proximal-Selective Hydroamination of Unactivated Alkenes
Jeon, Jinwon,Lee, Changseok,Seo, Huiyeong,Hong, Sungwoo
supporting information, p. 20470 - 20480 (2020/11/27)
Reported herein is a modular, NiH-catalyzed system capable of proximal-selective hydroamination of unactivated alkenes with diverse amine sources. The key to the successful implementation of this approach is the promotion of NiH insertion into even highly substituted olefins via coordination of the bidentate directing group to the nickel complex. A wide range of primary and secondary amines can be installed in both internal and terminal unactivated alkenes with excellent regiocontrol under the optimized reaction conditions. This protocol is flexible and general for the preparation of a variety of valuable β- and γ-amino acid building blocks that would otherwise be difficult to synthesize. The utility of this transformation was further demonstrated by the site-selective late-stage modification of complex and medicinally relevant molecules. Combined experimental and computational studies illuminate the detailed reaction mechanism.
A very mild and selective method for O-benzoylation of hydroxamic acids
Zheng, Yongsheng,Liu, Muqiong,Yuan, Yu
supporting information, p. 4404 - 4406 (2014/07/22)
Selective O-benzoylation of hydroxamic acids is achieved by the treatment of BPO and DABCO. Aliphatic alcohols are not reactive under these conditions. Various radical or oxidation sensitive functional groups are compatible with this protocol, and no anhydrous reagents or solvents are required for the high yields of the benzoylations.
