76437-40-6

Usage

Uses

Used in Analytical Chemistry:
TTBB is used as a derivatization reagent for the characterization and quantitation of DNA and hemoglobin adducts. Its unique structure allows for effective labeling and detection of these biologically significant molecules, enhancing the sensitivity and accuracy of analytical techniques.
Used in Gas Chromatography-Electron-Capture Negative Ion Mass Spectrometry (GC-ECNI-MS):
TTBB serves as an alternative to PFBB in electrophoric derivatization reactions prior to detection during GC-ECNI-MS. This application allows for the analysis of compounds that may be difficult to detect using traditional methods, providing a valuable tool for researchers in various fields.

InChI:InChI=1/C8H2BrF7/c9-1-2-4(10)6(12)3(8(14,15)16)7(13)5(2)11/h1H2

Upstream product

• 79674-46-7 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl alcohol 
• 954-15-4 2,3,5,6-tetrafluoro-4-(methoxycarbonyl)benzoic acid 
• 727-55-9 dimethyl 2,3,5,6-tetrafluoroterephthalate 
• 652-36-8 2,3,5,6-tetrafluoroterephthalic acid 
• 727-54-8 2,3,5,6-tetrafluoro-(4-ethoxycarbonyl)benzoic acid 
• 963-46-2 diethoxy 2,3,5,6-tetrafluoroterephthalate 
• 778-35-8 1,2,4,5-tetrafluoro-3-methyl-6-(trifluoromethyl)benzene 

Downstream Products

• 640290-67-1 2-hydroxy-TTBA 

Relevant academic research and scientific papers

New preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene

The invention discloses a new preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene. The method comprises the steps that with a compound 2,3,5,6-tetrafluoro-terephthalicacid as a raw material, through alkylation, 2,3,5,6-tetrafluoro-terephthalic acid diester is obtained firstly, then single hydrolysis is conducted, formic acid is fluorinated into trifluoromethyl so as to obtain 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate, and after the 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate is reduced into alcohol, through bromination, the target compound is obtained.According to the method, the reaction raw materials are easy to obtain and low in price, few reaction by-products are generated, and the product is easy to purify, high in yield and suitable for massindustrial production; therefore, reliable guarantee is provided for a key intermediate of a novel drug 2-hydroxyl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl benzylamino)benzoic acid.

Halogenated esters

Compounds of formula I wherein R1 and R2 are each selected from halomethyl and halo and R is nitro, cyano, lower alkoxycarbonyl, lower alkylcarbonyl, or di- or trifluoromethyl, and n has a value of zero to four, and compositions comprising them are useful as insecticides in agriculture, horticulture and other outlets. They may optionally be combined with other pesticides and/or synergists. The compounds may be prepared by conventional esterification processes from the corresponding acids and appropriately substituted benzyl alcohols or halides, some of which are novel. STR1