79674-46-7

Usage

Chemical compound

Benzenemethanol, 2,3,5,6-tetrafluoro-4-(trifluoromethyl)-

Physical state

Colorless liquid

Uses

Solvent
Intermediate
Reactant in organic synthesis

Characteristics

Stable chemical properties
Low toxicity

Applications

Production of pharmaceuticals
Production of agrochemicals
Production of specialty chemicals
Electronics industry for producing fluorine-containing materials.

Upstream product

• 954-15-4 2,3,5,6-tetrafluoro-4-(methoxycarbonyl)benzoic acid 
• 727-55-9 dimethyl 2,3,5,6-tetrafluoroterephthalate 
• 652-36-8 2,3,5,6-tetrafluoroterephthalic acid 
• 727-54-8 2,3,5,6-tetrafluoro-(4-ethoxycarbonyl)benzoic acid 
• 963-46-2 diethoxy 2,3,5,6-tetrafluoroterephthalate 

Downstream Products

• 76437-40-6 2,3,5,6-tetrafluoro-4-trifluoromethyl benzyl bromide 
• 916214-60-3 2-hydroxy-5-[(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylidene)-amino]-benzoic acid 
• 640290-67-1 2-hydroxy-TTBA 
• 187835-67-2 2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzaldehyde 

Relevant academic research and scientific papers

New preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene

The invention discloses a new preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene. The method comprises the steps that with a compound 2,3,5,6-tetrafluoro-terephthalicacid as a raw material, through alkylation, 2,3,5,6-tetrafluoro-terephthalic acid diester is obtained firstly, then single hydrolysis is conducted, formic acid is fluorinated into trifluoromethyl so as to obtain 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate, and after the 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate is reduced into alcohol, through bromination, the target compound is obtained.According to the method, the reaction raw materials are easy to obtain and low in price, few reaction by-products are generated, and the product is easy to purify, high in yield and suitable for massindustrial production; therefore, reliable guarantee is provided for a key intermediate of a novel drug 2-hydroxyl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl benzylamino)benzoic acid.

Method for producing cyclopropanecarboxylates

There is provided a method for producing a cyclopropanecarboxylate of formula (1): 1which comprises contacting a cyclopropanecarboxylate of formula (2): 2with a monohydroxy compound of formula (3):R7OH??(3)in the presence of a lithium compound of formula (4):R8OLi??(4),wherein R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, or a substituted or unsubstituted aryl group; R6 represents an alkyl group having 1 to 10 carbon atoms or a substituted or unsubstituted phenyl group; R7 and R8 do not simultaneously represent the same and each independently represent a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group.