727-55-9Relevant academic research and scientific papers
An air-stable anionic two-dimensional semiconducting metal-Thiolate network and its exfoliation into ultrathin few-layer nanosheets
He, Jun,He, Yonghe,Huang, Yitao,Liao, Wei-Ming,Wang, Lei,Xu, Gang,Xu, Zhengtao,Zeller, Matthias,Zeng, Qi,Zheng, Sai-Li
, p. 3645 - 3648 (2020)
The black, small-bandgap semiconducting framework Eu-dfdmat features extensive Eu3+-sulfur bridges from the linear linker 2,5-difluoro-3,6-dimercaptoterephthalate (dfdmt). Each Eu center is chelated to four dfdmt linkers to form an anionic coor
New preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene
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Paragraph 0034-0035, (2019/08/20)
The invention discloses a new preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene. The method comprises the steps that with a compound 2,3,5,6-tetrafluoro-terephthalicacid as a raw material, through alkylation, 2,3,5,6-tetrafluoro-terephthalic acid diester is obtained firstly, then single hydrolysis is conducted, formic acid is fluorinated into trifluoromethyl so as to obtain 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate, and after the 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate is reduced into alcohol, through bromination, the target compound is obtained.According to the method, the reaction raw materials are easy to obtain and low in price, few reaction by-products are generated, and the product is easy to purify, high in yield and suitable for massindustrial production; therefore, reliable guarantee is provided for a key intermediate of a novel drug 2-hydroxyl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl benzylamino)benzoic acid.
Method for preparing thiol-functionalized aryl carboxylic acid
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Paragraph 0058; 0062-0066; 0079-0083; 0092-0096, (2017/08/27)
The invention provides a method for preparing thiol-functionalized aryl carboxylic acid. The method comprises the following steps: A) protecting carboxyl of p-2,3,5,6-tetrafluoroterephthalic acid so as to obtain a midbody 1; B) performing a substitution r
Extending the series of p-substituted tetrafluorobenzoic acids: synthesis, properties and structure
Zaitsev, Kirill V.,Oprunenko, Yuri F.,Lermontova, Elmira Kh.,Churakov, Andrei V.
, p. 49 - 58 (2017/03/22)
The synthesis of the derivatives of p-aminotetrafluorobenzoic acid, p-H2NC6F4CO2H (2b), by hydrolysis, acylation or interaction with aldehydes was developed giving H2NC6F4CO2K (2a), C6F5C(O)N(H)C6F4CO2Et (3) and (E)-ArCH[dbnd]NC6F4CO2Et (4–11). The chemical derivatization of tetrafluoroterephthalic acid, p-HO2CC6F4CO2H (12), by hydrolysis, etherification and reduction was performed giving a number of symmetrical X(O)CC6F4C(O)X (13–15; X?=?Cl, NEt2, OMe) or unsymmetrical YC6F4CO2Me (15a–b, 16, 18–21; Y?=?CO2K, CO2H, CH2OH, C(O)Cl, C(O)C6H3(i-Pr)2, CO2CH2C6F4CO2Me, CO2C6H4Bu-t), HOCH2C6F4CO2H (17), [MeO2CC6F4]2Y (22, 23; Y?=?OCH2CH2O, N(H)C6H4N(H)) compounds. All substances were thoroughly investigated by spectroscopic methods (multinuclear NMR and IR spectroscopy, mass-spectrometry). The molecular structures of p-H2NC6F4CO2Et (2) and p-HO2CC6F4CO2Me (15b) have been determined by X-ray diffraction analysis.
Technology for preparing 2,3,5,6-tetrafluoro-1,4-benzenedimethanol
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Paragraph 0039; 0043; 0044, (2017/05/16)
The invention discloses a technology for preparing 2,3,5,6-tetrafluoro-1,4-benzenedimethanol, and belongs to the technical field of fine chemical synthesis. The technology includes the following reaction steps that (1) dry hydrogen chloride gas is led into 2,3,5,6-tetrafluoro-1,4-terephthalonitrile in an ether solvent for reaction, then low carbon alcohol is added for reaction, and a solution of 2,3,5,6-tetrafluoro-1,4-imino-terephthalate is obtained; (2) the 2,3,5,6-tetrafluoro-1,4-imino-terephthalate is reacted with water, an organic phase substance is collected and washed with water to be neutral, the solvent is removed in a vacuum distillation mode, and 2,3,5,6-tetrafluoro-1,4-terephthalic acid diester is obtained; (3) the 2,3,5,6-tetrafluoro-1,4-terephthalic acid diester is subjected to a catalyzed hydrogeneration reduction reaction, an organic phase substance is collected, cooled, subjected to suction filtration and dried, and the 2,3,5,6-tetrafluoro-1,4-benzenedimethanol is obtained. The technology has the advantages that the raw materials are low in cost, operation is easy and convenient, and high-concentration acid wastewater is avoided.
CARBOXYLATION CATALYSTS
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Paragraph 0102, (2013/04/13)
The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.
ALKALI METAL FLUORIDE DISPERSION AND PROCESS FOR PRODUCING FLUORINE-CONTAINING ORGANIC COMPOUND USING THE SAME
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Page/Page column 8; 9, (2011/05/16)
An alkali metal fluoride dispersion essentially consisting of an alkali metal fluoride and an aprotic organic solvent obtainable by conducting the following Step (A), subsequently conducting the following Step (B) at least once, and then conducting the following Step(C); Step (A): a step of separating a liquid phase from an alkali metal fluoride dispersion comprising at least one alcohol solvent selected from the group consisting of methanol, ethanol and isopropanol and an alkali metal fluoride, and mixing the separated liquid phase with an aprotic organic solvent having a boiling point of 85° C. or higher at normal pressure to obtain a mixture containing the alkali metal fluoride; Step (B): a step of obtaining a mixture containing the alkali metal fluoride comprising the following Steps (b1) to (b3); Step (b1): a step of concentrating the mixture containing the alkali metal fluoride obtained in Step (A) or Step (b3) to obtain a concentrated fraction and a concentrated residue; Step (b2): a step of mixing a residue of the alkali metal fluoride dispersion obtained by separating the liquid phase in Step (A) or a residue of the mixture obtained by separating a liquid phase in Step (b3) with the concentrated fraction obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (b3): a step of separating a liquid phase from the mixture containing an alkali metal fluoride obtained in Step (b2) and mixing the separated liquid phase with the concentrated residue obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (C): a step of removing the alcohol solvent from the mixture containing the alkali metal fluoride, which is obtained in Step (B), to obtain the alkali metal fluoride dispersion essentially consisting of the alkali metal fluoride and the aprotic organic solvent.
BORON OR ALUMINUM COMPLEXES
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Page/Page column 23, (2011/08/02)
The present invention relates to boron and aluminum complexes, to the preparation thereof, and to the use thereof for solubilizing ionic compounds. The complexes have one of the following formulae: in which D represents B or Al; R1 represents R, RF, NO2, CN, C(═O)OR, RSO2, or RFSO2; —X1—, —X2—, —X3— and X4 each represent a divalent group >C═O, >C═NC≡N, >C═C(C≡N)2, >CR2R3 or >SO2; —Y1—, —Y2— and —Y3— each represent a divalent group —O—, >N(C≡N), >N(CORF), >N(SO2R4), >NR4, >N(COR4) or >N(SO2RF); R, R2 and R3 each represent H, an alkyl group, an aryl group, an alkylaryl group, an arylalkyl group, an oxaalkyl group or an alkenyl group; R4 represents an alkyl group, an aryl group, an alkylaryl group, a heteroaryl group, an arylalkyl group, an oxaalkyl group, an alkenyl group or an RFCH2— group; RF is a perfluoroalkyl group, a partially fluorinated alkyl group, or a partially or totally fluorinated phenyl group; each of the R′2 and R′3 groups represents R or F.
Trifluoro-3-hydroxy-1H-indazolecarboxylic acids and esters from perfluorinated benzenedicarboxylic acids
Medina, Carlos Perez,Lopez, Concepcion,Claramunt, Rosa M.,Elguero, Jose
scheme or table, p. 890 - 899 (2010/04/23)
Twelve new 3-hydroxyindazoles, each bearing three fluorine substituents and a CO2R group (R = H, CH3, C2H5) distributed around its 4-, 5-, 6-, and 7-positions, have been synthesized. They were studied by NMR in
POTASSIUM FLUORIDE DISPERSION SOLUTION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME
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Page/Page column 6-9, (2009/04/25)
A potassium fluoride dispersion essentially consisting of potassium fluoride and an aprotic organic solvent having a boiling point higher than that of methanol, which is obtainable by mixing a mixture containing potassium fluoride and 5 to 50 parts by weight of methanol per 1 part by weight of potassium fluoride with the aprotic organic solvent followed by concentrating the obtained mixture, and a process for producing a fluorine-containing organic compound comprising contacting an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom with the potassium fluoride dispersion.
