963-46-2

Usage

Common Use

Plasticizer in industrial applications

Physical State

Clear, colorless liquid

Solubility

Insoluble in water

Boiling Point

High boiling point

Function

Makes plastics more flexible and durable

Common Products

Vinyl flooring, wire and cable insulation, automotive parts

Safety Precautions

Handle with caution, may be harmful if swallowed, inhaled, or absorbed through the skin

Environmental Impact

May have detrimental effects on the environment if released into the air, water, or soil

Upstream product

• 64-17-5 ethanol 
• 652-36-8 2,3,5,6-tetrafluoroterephthalic acid 
• 1835-49-0 tetrafluoroterephthalonitrile 

Downstream Products

• 79674-46-7 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl alcohol 
• 727-54-8 2,3,5,6-tetrafluoro-(4-ethoxycarbonyl)benzoic acid 
• 4084-38-2 (2,3,5,6-tetrafluorophenyl)methanol 
• 92339-07-6 2,3,5,6-tetrafluoro-1,4-benzenedimethanol 

Relevant academic research and scientific papers

New preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene

The invention discloses a new preparation method of 1-bromo-methyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene. The method comprises the steps that with a compound 2,3,5,6-tetrafluoro-terephthalicacid as a raw material, through alkylation, 2,3,5,6-tetrafluoro-terephthalic acid diester is obtained firstly, then single hydrolysis is conducted, formic acid is fluorinated into trifluoromethyl so as to obtain 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate, and after the 2,3,5,6-tetrafluoro-4-trifluoromethyl benzoate is reduced into alcohol, through bromination, the target compound is obtained.According to the method, the reaction raw materials are easy to obtain and low in price, few reaction by-products are generated, and the product is easy to purify, high in yield and suitable for massindustrial production; therefore, reliable guarantee is provided for a key intermediate of a novel drug 2-hydroxyl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl benzylamino)benzoic acid.

Technology for preparing 2,3,5,6-tetrafluoro-1,4-benzenedimethanol

The invention discloses a technology for preparing 2,3,5,6-tetrafluoro-1,4-benzenedimethanol, and belongs to the technical field of fine chemical synthesis. The technology includes the following reaction steps that (1) dry hydrogen chloride gas is led into 2,3,5,6-tetrafluoro-1,4-terephthalonitrile in an ether solvent for reaction, then low carbon alcohol is added for reaction, and a solution of 2,3,5,6-tetrafluoro-1,4-imino-terephthalate is obtained; (2) the 2,3,5,6-tetrafluoro-1,4-imino-terephthalate is reacted with water, an organic phase substance is collected and washed with water to be neutral, the solvent is removed in a vacuum distillation mode, and 2,3,5,6-tetrafluoro-1,4-terephthalic acid diester is obtained; (3) the 2,3,5,6-tetrafluoro-1,4-terephthalic acid diester is subjected to a catalyzed hydrogeneration reduction reaction, an organic phase substance is collected, cooled, subjected to suction filtration and dried, and the 2,3,5,6-tetrafluoro-1,4-benzenedimethanol is obtained. The technology has the advantages that the raw materials are low in cost, operation is easy and convenient, and high-concentration acid wastewater is avoided.

Trifluoro-3-hydroxy-1H-indazolecarboxylic acids and esters from perfluorinated benzenedicarboxylic acids

Twelve new 3-hydroxyindazoles, each bearing three fluorine substituents and a CO2R group (R = H, CH3, C2H5) distributed around its 4-, 5-, 6-, and 7-positions, have been synthesized. They were studied by NMR in