764669-06-9Relevant academic research and scientific papers
Divergent Synthesis of Tunable Cyclopentadienyl Ligands and Their Application in Rh-Catalyzed Enantioselective Synthesis of Isoindolinone
Cui, Wen-Jun,Wu, Zhi-Jie,Gu, Qing,You, Shu-Li
supporting information, p. 7379 - 7385 (2020/08/19)
A series of rhodium complexes bearing sterically and electronically tunable cyclopentadienyl ligands, prepared by utilizing Co2(CO)8-mediated [2+2+1] cyclization as a key step, were synthesized. In the presence of 2.5 mol% of CpmRh4, unprecedented enantioselective [4+1] annulation reaction of benzamides and alkenes was achieved with a broad substrate scope under mild reaction conditions, providing a variety of isoindolinones with excellent regio-and enantioselectivity (up to 94% yield, 97:3 er). Preliminary mechanistic studies suggest that the reaction involves an oxidative Heck reaction and an intramolecular enantioselective alkene hydroamination reaction.
Rhodium complex, preparation method thereof, intermediate and application (by machine translation)
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Paragraph 0233-0236; 0239, (2019/04/11)
The invention discloses a rhodium complex, preparation method thereof, intermediate and application. The invention of the rhodium complex structure and is shown as (R)- K or (S)- K is shown. The invention of the rhodium compound in the isoindole compounds
The Vibrational Circular Dichroism Pattern of the ν(C=O) Bands in Isoindolinones
Rode, Joanna E.,Lyczko, Krzysztof,Jawiczuk, Magdalena,Kaw?cki, Robert,Stańczyk, Wojciech,Jaglińska, Agnieszka,Dobrowolski, Jan Cz.
, p. 2411 - 2422 (2018/09/18)
The IR and vibrational circular dichroism (VCD) spectra of both enantiomers of Me-, iPr-, nBu-, Ph-, and CH2Ph-substituted isoindolinones in solution and KBr pellets were measured and interpreted by DFT calculations. The spectra in solution revealed no important differences in the C=O stretching vibration region while the interpretation of very distinct spectra taken in pellets required determining the crystal structures. The studied compounds crystallized in the P212121 (Me, iPr, CH2Ph), P31 (nBu), and P21 (Ph) space groups. We found that the quality of simulated spectra strongly depends on the substituent, the structure of the molecular cluster assumed, basis set, and use of the dispersion correction. The IR spectra can be reproduced well based on the simplest linear arrangement of hydrogen-bonded chains mimicking the molecular arrangement in the crystals. We found no common approach to reproduce all the registered VCD spectra in the crystal phase. For the Me and nBu isoindolinones, the VCD pattern was the best reproduced by full optimization of the selected large molecular clusters. For iPr, Ph and CH2Ph derivatives optimizing only the position of H-atoms in a fragment frozen as in the crystal provides the best results. Such an approach can reduce the computation time from months to one week.
Asymmetric hydrogenolysis of racemic tertiary alcohols, 3-substituted 3-hydroxyisoindolin-1-ones
Chen, Mu-Wang,Chen, Qing-An,Duan, Ying,Ye, Zhi-Shi,Zhou, Yong-Gui
supporting information; experimental part, p. 1698 - 1700 (2012/03/11)
Asymmetric hydrogenolysis of racemic tertiary alcohols, 3-substituted 3-hydroxyisoindolin-1-ones, was developed using chiral phosphoric acid as catalyst and a Hantzsch ester as the hydrogen source with up to 95% ee. The reaction process of this asymmetric
