76471-94-8

Usage

Uses

Used in Pharmaceutical Industry:
[(4-fluorophenyl)amino]acetonitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications, contributing to the advancement of medical treatments.
Used in Agricultural Chemical Industry:
In the agricultural sector, [(4-fluorophenyl)amino]acetonitrile is utilized as a starting material for the production of agricultural chemicals. Its incorporation into these chemicals can enhance their effectiveness in protecting crops and improving overall agricultural productivity.
Used in Dye and Pigment Manufacturing:
[(4-fluorophenyl)amino]acetonitrile is also employed as an intermediate in the manufacturing of dyes and pigments. Its chemical properties enable the creation of a wide range of colors and hues, catering to the diverse needs of various industries, such as textiles, plastics, and printing.
Safety Precautions:
It is essential to handle [(4-fluorophenyl)amino]acetonitrile with care, as it can be harmful if ingested or inhaled. Additionally, it can cause skin and eye irritation upon contact. Proper safety measures, including the use of personal protective equipment and adherence to safety guidelines, should be taken to minimize the risk of exposure and potential health hazards.

InChI:InChI=1/C8H7FN2/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4,11H,6H2

Upstream product

• 50-00-0 formaldehyd 
• 371-40-4 4-fluoroaniline 
• 7677-24-9 trimethylsilyl cyanide 
• 459-25-6 N-(4-fluorophenyl)formamide 
• 151-50-8 potassium cyanide 

Downstream Products

• 1204614-44-7 (p-fluorophenyl)iminoacetonitrile 
• 1204614-41-4 2-(p-fluorophenyl)iminomalononitrile 
• 946505-86-8 3,5-dichloro-1-(4-fluorophenyl)pyrazin-2(1H)-one 
• 864910-76-9 2-((4-fluorophenyl)(methyl)amino)acetonitrile 

Relevant academic research and scientific papers

Iron-catalyzed reductive strecker reaction

Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI2-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN? was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (13C labeled) complex molecules from CO2 via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.

PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES

Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.

Ion Channel Modulators

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

ION CHANNEL MODULATORS

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.