76471-94-8

Basic information

• Product Name: [(4-fluorophenyl)amino]acetonitrile
• Synonyms: [(4-fluorophenyl)amino]acetonitrile
• CAS NO: 76471-94-8
• Molecular Formula: C₈H₇FN₂
• Molecular Weight: 150.1529832
• EINECS: 278-475-0
• Mol File: 76471-94-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 301.3°C at 760 mmHg
• Flash Point: 136°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.00107mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: [(4-fluorophenyl)amino]acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-fluorophenyl)amino]acetonitrile(76471-94-8)
• EPA Substance Registry System: [(4-fluorophenyl)amino]acetonitrile(76471-94-8)

Safety Data

• Hazardous Substances Data: 76471-94-8(Hazardous Substances Data)

Usage

General Description

[(4-fluorophenyl)amino]acetonitrile is a chemical compound with the molecular formula C8H7FN2. It is a crystalline solid and is used as a building block in the synthesis of various pharmaceuticals and agricultural chemicals. It is also used as an intermediate in the manufacturing of dyes and pigments. [(4-fluorophenyl)amino]acetonitrile is a versatile compound that can undergo various reactions to produce a wide range of derivatives, making it a valuable component in the production of diverse chemical products. It is important to handle this chemical with caution, as it can be harmful if ingested or inhaled, and can cause skin and eye irritation upon contact.

InChI:InChI=1/C8H7FN2/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4,11H,6H2

Upstream product

• 151-50-8 potassium cyanide 
• 371-40-4 4-fluoroaniline 
• 7677-24-9 trimethylsilyl cyanide 
• 459-25-6 N-(4-fluorophenyl)formamide 
• 50-00-0 formaldehyd 

Downstream Products

• 946505-86-8 3,5-dichloro-1-(4-fluorophenyl)pyrazin-2(1H)-one 
• 1204614-44-7 (p-fluorophenyl)iminoacetonitrile 
• 1204614-41-4 2-(p-fluorophenyl)iminomalononitrile 
• 864910-76-9 2-((4-fluorophenyl)(methyl)amino)acetonitrile 

Relevant articles and documents

Iron-catalyzed reductive strecker reaction

Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI2-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN? was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (13C labeled) complex molecules from CO2 via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.

Ion Channel Modulators

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.