459-25-6

Basic information

• Product Name: 1-FLUORO-4-FORMAMIDOBENZENE
• Synonyms: N-(4-FLUOROPHENYL)FORMAMIDE;4'-FLUOROFORMANILIDE;1-FLUORO-4-FORMAMIDOBENZENE;NSC40549;N-(4-fluorophenyl)methanamide;1-Fluoro-4-formamidobenzene 4'-Fluoroformanilide;N-(4-Fluorophenyl)formamide;N-(4-Fluorophenyl)formamidine
• CAS NO: 459-25-6
• Molecular Formula: C₇H₆FNO
• Molecular Weight: 139.13
• Mol File: 459-25-6.mol
• Article Data: 77

Chemical Properties

• Melting Point: 67 °C
• Boiling Point: 278.5°Cat760mmHg
• Flash Point: 122.3°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.00424mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-FLUORO-4-FORMAMIDOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FLUORO-4-FORMAMIDOBENZENE(459-25-6)
• EPA Substance Registry System: 1-FLUORO-4-FORMAMIDOBENZENE(459-25-6)

Safety Data

• Hazardous Substances Data: 459-25-6(Hazardous Substances Data)

Usage

General Description

1-Fluoro-4-formamidobenzene is an organic chemical compound with the molecular formula C7H6FNO. It is a derivative of a benzene ring with a fluoro and formamide functional group attached. 1-FLUORO-4-FORMAMIDOBENZENE is used in various research applications, especially in pharmaceutical and agrochemical industries. Its unique structure makes it useful in the synthesis of other organic compounds and it may also have potential medicinal properties. However, it is important to handle this chemical with caution and follow safety protocols as it may pose health hazards if not properly handled.

InChI:InChI=1/C7H6FNO/c8-6-1-3-7(4-2-6)9-5-10/h1-5H,(H,9,10)

Upstream product

• 64-18-6 formic acid 
• 371-40-4 4-fluoroaniline 
• 1195-45-5 para-fluorophenyl isocyanate 
• 459-59-6 4-fluoro-N-methylaniline 
• 403-46-3 4-fluoro-N,N-dimethylaniline 
• 51673-84-8 dimethoxyacetaldehyde 
• 124-38-9 carbon dioxide 
• 350-46-9 4-Fluoronitrobenzene 
• 16664-09-8 4-fluorobenzoyl azide 
• 667-27-6 Ethyl bromodifluoroacetate 
• 123-91-1 1,4-dioxane 
• 456-07-5 4-fluorobenzohydroxamic acid 
• 77287-34-4 formamide 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 24075-34-1 4-fluorophenyl isocyanide 
• 154592-60-6 1-fluoro-4-isoselenocyanatobenzene 
• 74701-95-4 C₆H₄FN(CHO)SCFCl₂ 
• 153885-60-0 N-(4-fluorophenyl)hydrazinecarboxamide 
• 79175-43-2 N-(3,4,5-trichlorophenylmercuri)-4-fluoroformanilide 
• 79175-47-6 N-(4-methylphenylmercuri)-4'-fluoroformanilide 
• 79175-46-5 N-(4-chlorophenylmercuri)-4'-fluoroformanilide 
• 79175-44-3 N-(3,4-dichlorophenylmercuri)-4'-fluoroformanilide 
• 154592-72-0 N-(4-fluorophenyl)selenocarbamate of cholestanol 
• 154592-66-2 O-cyclododecyl-N-(4-fluorophenyl)selenocarbamate 
• 403-46-3 4-fluoro-N,N-dimethylaniline 
• 459-59-6 4-fluoro-N-methylaniline 

Relevant articles and documents

Access to Unsymmetrically Substituted Diaryl Gold N-Acyclic Carbene (NAC) and N-Heterocyclic Carbene (NHC) Complexes via the Isonitrile Route

A variety of unsymmetric diaryl gold N-acyclic carbene (NAC) complexes was synthesized via the isonitrile route by three different methods: (a) solvent free in a melt, (b) mechanochemically and (c) in THF at room temperature. The latter method can also be used to synthesize unsaturated gold NHC complexes. These methods overall offer access to a broad array of new complexes and remove one of the previous limitations of the isonitrile route to NAC and NHC complexes of gold, namely the inability to react with the less nucleophilic aromatic amines. The new complexes also proved to be successful as pre-catalysts in the gold-catalyzed phenol synthesis. (Figure presented.).

Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents

Two series of novel 4-phenoxypyridine derivatives containing imidazole-4-carboxamide and 4-methyl-5-oxo-4,5-dihydro-1,2,4-triazole-3-carboxamide moieties were synthesized and evaluated for their in vitro inhibitory activities against c-Met kinase and anti

Preparation and catalytic evaluation of a palladium catalyst deposited over modified clinoptilolite (Pd&at;MCP) for chemoselective N-formylation and N-acylation of amines

Novel palladium nanoparticles stabilized by clinoptilolite as a natural inexpensive zeolite prepared and used for N-formylation and N-acylation of amines at room temperature at environmentally benign reaction conditions in good to excellent yields. Pd (II) was immobilized on the surface of clinoptilolite via facile multi-step amine functionalization to obtain a sustainable, recoverable, and highly active nano-catalyst. The structural and morphological characterizations of the catalyst carried out using XRD, FT-IR, BET and TEM techniques. Moreover, the catalyst is easily recovered using simple filtration and reused for 7 consecutive runs without any loss in activity.