76504-50-2Relevant academic research and scientific papers
Preparation of 3-fluoro-5-hydroxy-4--2(5H)-furanone
Komatsu, Yuzo,Kitazume, Tomoya
, p. 101 - 104 (1998)
Synthesis of 3-fluoro-5-hydroxy-4--2(5H)-furanone as an inhibitor of the phospholipase A2 (PLA2) was described. - Keywords: Bioactive materials; Inhibitor
Synthesis and Spectral Characterization of γ-Hydroxy-Δα,β-butenolides Possessing a Conjugated Substituent at the β-Position
Ito, Masayoshi,Iwata, Tsutomu,Tsukida, Kiyoshi
, p. 4346 - 4351 (2007/10/02)
Conjugated γ-hydroxybutenolides (6a-h, 10, and 11) were synthesized in three steps starting from various aldehydes (3a-h and 7), and their spectral characteristics were compared with those of unconjugated butenolides (12 and 13).Keywords-conjugated γ-hydr
OXYGEN TRANSFER DURING THE COPPER INDUCED REACTION OF α,β-EPOXY DIAZOMETHYL KETONES
Thijs, L.,Zwanenburg, B.
, p. 2145 - 2148 (2007/10/02)
Reactions of α,β-epoxy diazomethyl ketones 1a-i with activated copper powder or copper(II) sulfate in methanol (or ethanol) lead to 1,1-dialkoxy-but-3-ene-2-ones 2 (or 3) in good yields.This process of oxygen transfer proceeds via initially generated keto-carbenoids which react intramolecularly with the epoxide function to give bicyclic intermediates 10.Release of strain and subsequent ring opening produces but-2-ene-1,2-diones which acetalise to give the ultimate reaction products 2 (or 3).With copper as catalyst byproducts were isolated viz 1,1-dialkoxy-4-hydroxy-butane-2-ones (4 and 5), and indanone derivate 6.An explanation for these side reactions has been given.
