7662-13-7Relevant academic research and scientific papers
Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F
Zan, Xin,Gao, Jian,Gu, Guofeng,Liu, Shanshan,Sun, Bin,Liu, Lei,Lou, Hong-Xiang
supporting information, p. 1600 - 1604 (2014/03/21)
Both the sugar moieties and aglycons of steroid saponins play important roles for their bioactivities. In order to test the biological contribution of the glycosyl residue and search new saponins with notable anticancer activity, mono- and di-saccharide p
Synthesis and cytotoxicities of icogenin analogues with disaccharide residues
Wang, Haixing,Su, Fuqin,Zhou, Liang,Chen, Xiaoguang,Lei, Pingsheng
supporting information; experimental part, p. 2796 - 2800 (2010/04/05)
For further structure-activity relationships (SAR) research of furostan saponin, two icogenin analogues: (25R)-22-O-methyl-furost-5-en-3β,26-diol-3-O-α-l-rhamnopyrano syl-(1 → 2)-β-d-glucopyranoside 1 and (25R)-22-O-methyl-furost-5-en-3β,26-diol-3-O-α-l-r
KHSO4-SiO2-MeOH An efficient selective solid-supported system for deprotection of alcohols from esters
Goswami, Amrit,Das, Ram N.,Borthakur, Naleen
, p. 1893 - 1895 (2008/09/19)
KHSO4-SiO2 can efficiently deprotect alcohols from esters through transesterification in methanol under mild condition. Esters of aromatic alcohols are easily transesterified at room temperature compared to the corresponding aliphatic or alicyclic alcohol. NAcetyl compounds and ethers are resistant to the reagent under the above condition. The method is very useful for preparation of biodiesel methyl ricinoleate from castor oil.
Spirostanols obtained by cyclization of pseudosaponin derivatives and comparison of anti-platelet agglutination activities of spirostanol glycosides
Tobari, Akihiko,Teshima, Mutsumi,Koyanagi, Junich,Kawase, Masami,Miyamae, Hiroshi,Yoza, Kenji,Takasaki, Akihiko,Nagamura, Yoich,Saito, Setsuo
, p. 511 - 527 (2007/10/03)
Naturally occurring saponins 3 and 4 have a normal type F ring and α- arranged CH3-21 group. Treatments of pseudosaponin peracetates 18 and 19 derived from 3 and 4, respectively, with alcoholic KOH, followed by acidification with acetic acid, gave spirostanols 20 and 22 having iso type F rings as major products. Structural analyses of sapogenins and saponins derived from pseudo derivatives 11, 12, 18 and 19 were performed by comparisons of their 1H-NMR spectral data and the X-ray analytical data of 3-O-p-bromobenzoyl sarsasapogenin 7, 3-O-acetyl diosgenin 13 and saponin 20. The mechanisms of ring-closure reaction of the side chain at C-22 of pseudosapogenins and pseudosaponins were deduced using stereomodels of the spirostanols derived from 11 under various reaction conditions. Inhibitory activities of saponin diglycosides 3, 4, 20, 21 and 25 on human platelet agglutinations induced by ADP and ristocetin were compared. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
