2309-38-8Relevant academic research and scientific papers
Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs
Mancino, Valentina,Cerra, Bruno,Piccinno, Alessandro,Gioiello, Antimo
supporting information, p. 600 - 607 (2018/05/14)
A telescoped multistep process to provide the continuous delivery of 16-dehydropregnenolone acetate (16-DPA) from diosgenin is described. The method was evaluated through batch screenings that helped to identify critical bottlenecks and flowability, and the best conditions were optimized in flow systems before the individual steps were telescoped together into a single integrated flow process. Further highlights of our approach include the use of efficient in-line extraction operations and reaction monitoring, the avoidance of time-consuming purifications between steps, and improvement of efficiency and safety standards.
Studies on the Constituents of Solanaceous Plants. XIII. A New Steroidal Glucuronide from Chinese Solanum lyratum
Yahara, Shoji,Ohtsuka, Michiko (nee Ikeda),Nakano, Kimiko,Nohara, Toshihiro
, p. 1802 - 1804 (2007/10/02)
A new glucuronide, (22R)-3β,16β,22,26-tetrahydroxycholest-5-ene 3-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucuronopyranoside (1), was isolated from the aerial parts of Chinese Solanum lyratum THUNB.The structure of this new steroidal glucuronide was deduced by spectroscopic means and the identity of its aglycone was substantiated by comparison with an authentic sample derived from diosgenin acetate.Keywords - Solanaceae; Solanum lyratum; (22R)-3β,16β,22,26-tetrahydroxycholest-5-ene; rhamnosyl glucuronoside; diosgenin E,F-ring cleavage; aluminum chloride-acetic anhydride reaction.
