76649-98-4Relevant academic research and scientific papers
Synthesis of ring A fluorinated anthracyclines
Pasqui, Franco,Canfarini, Franca,Giolitti, Alessandro,Guidi, Antonio,Pestellini, Vittorio,Arcamone, Federico
, p. 185 - 198 (1996)
The synthesis of different anthracyclines of the daunorubicin family, fluorinated at position 8 or 10 is described. The 8-fluoroderivatives (2a-c) were obtained by glycosylation of the corresponding fluorinated aglycones. The 10-fluoroderivatives (2d-g) were synthesized directly from daunorubicin (1a) and idarubicin (1c) following a non deglycosidative approach. 8-(S)-Fluorodoxorubicin was obtained from 8-(S)-fluorodaunorubicin, although in very low yield. Copyright
