84863-67-2

Usage

Uses

Used in Pharmaceutical Industry:
[(1S)-3-methyl-1-[[(3-methylbutyl)amino] is used as an active pharmaceutical ingredient for [application reason], such as targeting specific biological pathways or receptors, due to its unique chemical structure and properties.
Used in Chemical Synthesis:
In the chemical synthesis industry, [(1S)-3-methyl-1-[[(3-methylbutyl)amino] is used as a building block or intermediate for the synthesis of more complex molecules, taking advantage of its reactive functional groups and structural features.
Used in Research and Development:
[(1S)-3-methyl-1-[[(3-methylbutyl)amino] is utilized in research and development as a model compound to study the effects of structural modifications on the properties and reactivity of amine-based molecules, contributing to the advancement of organic chemistry and related fields.
Used in Material Science:
In the material science field, [(1S)-3-methyl-1-[[(3-methylbutyl)amino] is used as a component in the development of novel materials with specific properties, such as improved conductivity, stability, or reactivity, based on its unique molecular structure and chemical characteristics.

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 541-23-1 isoamylamine hydrochloride 
• 107-85-7 1-amino-3-methylbutane 
• 200937-21-9 N-tert-butoxycarbonyl-L-leucine monohydrate 
• 3392-09-4 Boc-Leu-ONSu 
• 66866-44-2 Boc-Leu-O-COO-isoBu 

Downstream Products

• 84851-37-6 N¹-isoamylleucinamide 
• 88321-09-9 aloxistatin 
• 76684-89-4 loxistatin acid 
• 179082-53-2 (2S,3S)-Oxirane-2,3-dicarboxylic acid 2-(benzyloxy-amide) 3-{[(S)-3-methyl-1-(3-methyl-butylcarbamoyl)-butyl]-amide} 
• 1583283-69-5 C₂₁H₃₆N₃O₅P 
• 1583283-24-2 (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-isopentyl-4-methylpentanamide lithium 
• 84851-37-6 (S)-1-(isopentylamino)-2-amino-4-methyl-1-oxopentan hydrochloride 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR SYNTHESIZING (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYL-AMIDO-3-METHYLBUTANE ETHYL ESTER

In alternative embodiments the invention provides methods for synthesizing AB-007 (also called loxistatin, E64d, EST or ((2S,3S)-trans-epoxysuccinyl-L-leucyl-amido-3-methylbutane ethyl ester) and its acid form E64c (loxistatin acid), and various synthetic

Additivity or cooperativity: Which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?

Predicting how binding affinity responds to ligand structural modifications in structure-activity relationship studies (SAR) is a major challenge in medicinal chemistry. This is particularly true when two or more of these modifications are carried out simultaneously. In this study, we present binding affinity data from several series of thermolysin inhibitors in which simultaneous structural modifications were investigated to determine whether they are cooperative or additive. Data revealed that, while additivity is at work in some cases, cooperativity is more commonly demonstrated. Cooperativity and additivity were then correlated with ligand descriptors, such as the spacing and the topological features of the modified groups, in a manner that may provide guidance as to when each model should be utilized. Cooperativity was particularly associated with contiguous groups and small unbranched hydrophobic side chain. Additivity, on the other hand, was associated with moderately distant hydrophobic group combinations and side chain branching. Such correlations can improve the predictability of SAR studies and can provide a starting point for additional investigations that may lead to further significant enhancements in the current scoring functions.

Influence of neighboring groups on the thermodynamics of hydrophobic binding: An added complex facet to the hydrophobic effect

The thermodynamic consequences of systematic modifications in a ligand side chain that binds in a shallow hydrophobic pocket, in the presence and absence of a neighboring ligand carboxylate group, were evaluated using isothermal titration calorimetry (ITC

Design, synthesis, and screen of cathepsin K inhibitors

We synthesized a series of epoxysuccinic acid derivatives and evaluated their in vitro cathepsin K inhibitory activity The screening results show that the potency of compounds 9e, 9d, 9p, 9j and 9k (IC50 ≤ 0.005 μmol/L) were equal to or greater than that of the lead compound 9a. Less hydrophobic compounds showed weaker potency, which can be explained by the hydrophobic nature of the cathepsin K binding pockets.

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

The design, synthesis and evaluation of 3-methylene-substituted indolinones as falcipain inhibitors and antiplasmodial agents are described. These compounds react readily with thiols via an addition-elimination mechanism, indicating their potential as cys

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors

A series of 1,4-naphthoquinone derivatives diversely substituted at C-2, C-3, C-5 and C-8, prepared by reaction of amines, amino acids and alcohols with commercial 1,4-naphthoquinones, has been evaluated against papain and bovine spleen cathepsin B. These

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases

Carbamate and ester derivatives of the 1,1-dioxobenzo[b]thiophen-2-ylmethyloxycarbonyl (Bsmoc) scaffold react readily with thiols via a Michael addition at rates not significantly affected by the nature of the carboxylic or carbamic acid leaving group. These Michael acceptors are irreversible inhibitors of the cysteine proteases papain and human liver cathepsin B, displaying first-order kinetics with respect to inhibitor concentration. In contrast, none of the Bsmoc derivatives inhibited porcine pancreatic elastase, a serine protease.

Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides

The stereoselective synthesis of cathepsin inhibitors from indoline type epoxyamides is described. The use of this type of epoxyamides permitted the preparation of E-64 and CA-074 related compounds depending on the order in which the key steps, the oxidat

AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE

The present invention relates to a compound of the formula: STR1 wherein R 1 and Q are independently an optionally esterified or amidated carboxyl group; R 2 is hydrogen, an acyl group or an optionally substituted hydrocarbon residue; X is a divalent hydrocarbon residue which may be substituted; or a salt thereof, which is useful as prophylactic and therapeutic agents of bone diseases and as agents for inhibiting thiol protease.

Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors

Analogs of the epoxysuccinyl peptide cysteine proteinase inhibitor, EP- 475 (2a), in which the free carboxylate has been replaced by hydroxamic acid, amide, methyl ketone, hydroxyl, and ethyl ester functionalities, have been synthesized. Individual rate c