767264-65-3

Upstream product

• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 626-55-1 3-Bromopyridine 
• 107099-99-0 2,5-dimethoxyphenylboronic acid 
• 150129-94-5 (+/-)-ethyl (2-cyanoethyl)(2,5-dimethoxyphenyl)acetate 
• 66469-86-1 ethyl (2,5-dimethoxyphenyl)acetate 
• 150129-95-6 (+/-)-3-(2,5-dimethoxyphenyl)piperidin-2-one 

Relevant academic research and scientific papers

5-HT2A AGONISTS FOR USE IN TREATMENT OF DEPRESSION

The present invention relates to agonists of the 5-HT2A serotonin receptors and their medical uses. In one aspect the invention relates to 5-HT2A agonists of formula (I). In second aspect, the invention relates to selective 5-HT2A agonists of formula (II). In another aspect, the invention relates to mixed 5-HT2A/5-HT2C agonists of formula (III). In yet another aspect, the invention relates to 5-HT2A agonists for use in the treatment of a depressive disorder, more particular a 5-HT2A agonist for the use in the treatment of treatment-resistant depression.

2,5-Dimethoxy congeners of (+)- and (-)-3-(3-hydroxyphenyl)-N-n- propylpiperidine

p-Dimethoxyaryl analogs of certain potent catechol-derived dopaminergic agonists show dopaminergic properties for which no structure-activity relationship has yet been defined. (S)-3-(3-Hydroxyphenyl)-N-n- propylpiperidine (1, S-'3-PPP') is a dopaminergic