76732-75-7

Usage

Uses

Used in Neurological Disorders Treatment:
Picartamide is used as a neuroprotective agent for its potential role in the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease. Its modulation of GABA receptor activity, along with its anti-inflammatory and antioxidant properties, contribute to its therapeutic effects in these conditions.
Used in Neurology and Neuropharmacology Research:
Picartamide is used as a research compound in the field of neurology and neuropharmacology. Its potential therapeutic applications are currently being explored, with ongoing studies investigating its mechanisms of action and efficacy in treating various neurological conditions.

InChI:InChI=1/C11H14N2S2/c1-12-10(14)11(6-4-8-15-11)9-5-2-3-7-13-9/h2-3,5,7H,4,6,8H2,1H3,(H,12,14)

Upstream product

• 76732-76-8 2-(2-pyridyl)tetrahydrothiophene 
• 556-61-6 methyl thioisocyanate 
• 76743-15-2 2-Pyridin-2-yl-tetrahydro-thiophene-2-carbodithioic acid methyl ester 
• 74-89-5 methylamine 
• 76732-77-9 3-chloropropyl 2-pyridylmethyl sulfide 
• 1822-49-7 2-(2-pyridylmethyl)isothiourea dihydrochloride 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 2044-73-7 2-(sulfanylmethyl)pyridine 

Relevant academic research and scientific papers

Synthesis and Antisecretory and Antiulcer Activities of Derivatives and Analogues of 2-(2-Pyridyl)tetrahydrothiophene-2-carbothioamide

New thioamide derivatives of 2-(2-pyridyl)tetrahydrothiophene-2-carbothioamide (29) and related compounds (in which the tetrahydrothiophene ring was replaced by tetrahydrothiopyran, tetrahydrofuran, 1,3-dithiane, or 1,3-oxathiane and where the pyridine ring was repleaced by other nitrogen heterocycles) were synthesized and tested for their antisecretory and antiulcer activities.These thioamides were prepared according to one of the following methods: (i) reaction of an isothiocyanate with the carbanion of the corresponding cyclic precursor (for secondary thioamides); (ii) reaction of ammonia or an amine with the dithio ester prepared from the same precursor (for primary, secondary, and tertiary thioamides).These thioamides were evaluated by the Shay method to measure their antisecretory activity and by the stress-induced-ulcer method to test their antiulcer activity.Structure-activity relationships are discussed.N-Methyl-2-(2-pyridyl)tetrahydrothiophene-2-carbothioamide (R.P. 40749,30) exhibited activities that were at least 10 times higher than those reported for cimetidine.