76745-19-2

Basic information

• Product Name: (5S,6R)-Methyl 5-(benzyloxy)-6,7-dihydroxyheptanoate
• Synonyms: (5S,6R)-Methyl 5-(benzyloxy)-6,7-dihydroxyheptanoate
• CAS NO: 76745-19-2
• Molecular Weight: 296.32
• Mol File: 76745-19-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (5S,6R)-Methyl 5-(benzyloxy)-6,7-dihydroxyheptanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,6R)-Methyl 5-(benzyloxy)-6,7-dihydroxyheptanoate(76745-19-2)
• EPA Substance Registry System: (5S,6R)-Methyl 5-(benzyloxy)-6,7-dihydroxyheptanoate(76745-19-2)

Safety Data

• Hazardous Substances Data: 76745-19-2(Hazardous Substances Data)

Upstream product

• 76871-77-7 cis-7-hydroxy-5-heptenoic acid,methyl ester 
• 78606-78-7 methyl (E,5S,6R)-5,6,7-trihydroxyhept-2-enoate 
• 78606-80-1 5(S), 6(R), 7-trihydroxyheptanoic acid methyl ester 
• 76745-17-0 (5S,6R)-5,6-Dihydroxy-7-(toluene-4-sulfonyloxy)-heptanoic acid methyl ester 
• 533-67-5 2-Deoxy-D-ribose 
• 148407-21-0 (5R,6R)-methyl 7-(p-nitrobenzoyloxy)-5,6-epoxyheptanoate 
• 79356-62-0 (5R,6R)-epoxy-7-hydroxyheptanoic acid methyl ester 
• 65-85-0 benzoic acid 
• 111037-30-0 (5S,6R)-Methyl 5-(benzyloxy)-6,7-O-isopropylideneheptanoate 
• 78606-79-8 Benzoic acid (S)-4-methoxycarbonyl-1-(R)-oxiranyl-butyl ester 

Downstream Products

• 111037-31-1 Methyl (5S)-5-(Benzoyloxy)-7-bromohept-6-enoate 
• 78606-81-2 Benzoic acid (2Z,5Z)-(S)-1-(3-methoxycarbonyl-propyl)-6-[(2R,3R)-((Z)-3-oct-2-enyl)-oxiranyl]-hexa-2,5-dienyl ester 
• 71160-24-2 Leukotriene B 
• 76745-20-5 Methyl 5S-benzoyloxy-5-formylvalerate 

Relevant articles and documents

12-Oxo-LTB4, a key pivotal intermediate in LTB4 metabolism

The first total synthesis of the very unstable and elusive biochemical intermediate 5(S)-hydroxy-12-oxo-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid (12-oxo-LTB4) (2) has been accomplished. Incubation of the synthetic 12-oxo-LTB4 (2) with human keratinocytes produced 5(S),12-dihydroxy-6-glutathionyl-7(E),9(E),14(Z)-eicosatrienoic acid (c-LTB3) and 5(S),12-dihydroxy-6-cysteinylglycyl-7(E),9(E),14(Z)-eicosatrienoic acid (d-LTB3), two new intriguing mediators which have been identified recently during the incubations of LTB4 with keratinocytes. We have also confirmed the identity of 12-oxo-LTB4 prepared from porcine leukocytes by comparison with the synthetic material and identified the formation in these incubates of the 6-trans-isomer of 12-oxo-LTB4.

OPTICALLY ACTIVE PROPARGYLIC ALCOHOLS FROM D-XYLOSE USEFUL PRECURSORS FOR LTB4 SYNTHESIS

Using D-Xylose as a source of chirality at C-5 and C-12 in LTB4, an efficient synthesis of the optically active propargylic alcohols A and B, chiral precursors for the LTB4 synthesis, has been achieved.