76806-96-7Relevant academic research and scientific papers
DNA METHYL TRANSFERASE INHIBITORS CONTAINING A ZINC BINDING MOIETY
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Page/Page column 49-50, (2008/06/13)
The present invention relates to inhibitors of DNMT containing zinc moiety derivatives that have enhanced or unique properties as inhibitors of DNA methyl transferases (DNMT) and their use in the treatment of DNMT related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.
MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS
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Page/Page column 228, (2008/06/13)
The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.
N-phenethylaminoalkyl-benzamide anti-arrhythmia agents
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, (2008/06/13)
Compounds of the formula: and their pharmaceutically acceptable salts, wherein R1 and R5 are each independently C1-C4 alkyl; R2 and R3 are each independently H or C1-C4 alkyl; R4 is H or C
Procainamide antigen conjugates and antibodies
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, (2008/06/13)
Compounds are provided for use in the preparation of reagents which can be used in immunoassays for the determination of benzamides of N,N-dialkylethyleneamines. A linking group is provided, at a particular site of the drug, which provides a link between
