76816-54-1

Basic information

• Product Name: 1-(PROPANOYL)-PIPERAZINE
• Synonyms: 1-(PROPANOYL)-PIPERAZINE;1-(PROPIONYL)-PIPERAZINE;1-(Piperazin-1-yl)propan-1-one;1-Propanoylpiperazine, 1-(1-Oxoprop-1-yl)piperazine;1-Propanone,1-(1-piperazinyl)-;1-(piperazin-1-yl)propan-1-one HCl
• CAS NO: 76816-54-1
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.2
• Product Categories: piperazines
• Mol File: 76816-54-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 55 °C
• Boiling Point: 78 °C
• Flash Point: 118.3°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.00623mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: 1-(PROPANOYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(PROPANOYL)-PIPERAZINE(76816-54-1)
• EPA Substance Registry System: 1-(PROPANOYL)-PIPERAZINE(76816-54-1)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 76816-54-1(Hazardous Substances Data)

Usage

General Description

1-(Propanoyl)-Piperazine, also known as Propionylpiperazine, is a chemical compound that falls under the category of piperazines. Piperazines are a large group of chemical compounds, many with important pharmacological properties. It has the CAS registry number 2295-02-7 and molecular formula C7H14N2O. Its systematic name is noted as 1-(propanoyl)piperazine. It is chiefly used in scientific research, including pharmaceutical applications, where it often serves as an intermediate compound. Due to its potential role in creating pharmaceuticals, it should be handled carefully, avoiding eye or skin contact, and stored in a cool, dry place.

InChI:InChI=1/C7H14N2O/c1-2-7(10)9-5-3-8-4-6-9/h8H,2-6H2,1H3

Upstream product

• 110-85-0 piperazine 
• 74-85-1 ethene 
• 1327884-43-4 tert-butyl-4-propionylpiperazine-1-carboxylate 
• 314728-80-8 1-(4-benzyl-piperazin-1-yl)-propan-1-one 
• 123-62-6 propionic acid anhydride 
• 554-12-1 propanoic acid methyl ester 

Downstream Products

• 1259916-98-7 N-cyclohexyl-2-(4-propionylpiperazin-1-yl)acetamide 
• 1259917-36-6 N-cyclopentyl-2-(4-propionylpiperazin-1-yl)propanamide 
• 1259916-96-5 N-(pentan-3-yl)-2-(4-propionylpiperazin-1-yl)acetamide 
• 1198795-07-1 1-(4-phenylacetylpiperazin-1-yl)propan-1-one 
• 1198795-05-9 4-propionylpiperazine-1-carboxylic acid phenyl ester 
• 1198795-06-0 4-propionylpiperazine-1-carboxylic acid phenylamide 
• 5436-89-5 N,N'-dipropionylpiperazine 
• 3347-06-6 1-propionyl-4-(toluene-4-sulfonyl)-piperazine 

Relevant articles and documents

Benzofuran derivative as well as preparation method and medical application thereof

The invention relates to benzofuran derivatives, and a preparation method and medical application thereof. Specifically, the present invention relates to a new benzofuran derivative represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and application of the composition as a therapeutic agent, especially as a PAR-4 antagonist, wherein each substituent of general formula (I) is as defined in the specification.

CYCLIC AMINES AS BROMODOMAIN INHIBITORS

The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

New antiproliferative benzoindolinothiazepines derivatives

New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.