76816-54-1

Usage

Uses

Used in Pharmaceutical Applications:
1-(Propanoyl)-Piperazine is used as an intermediate compound in the development of pharmaceuticals for various therapeutic purposes. Its chemical structure allows for the synthesis of a wide range of drug molecules, making it a valuable component in the pharmaceutical industry.
Used in Scientific Research:
1-(Propanoyl)-Piperazine is used as a research compound in various scientific studies, particularly in the fields of chemistry and biology. Its unique properties and potential applications in drug development make it an essential tool for researchers exploring new therapeutic agents and understanding the underlying mechanisms of drug action.
Used in Drug Synthesis:
1-(Propanoyl)-Piperazine is used as a building block in the synthesis of various drug molecules. Its chemical reactivity and compatibility with other compounds enable the creation of new pharmaceuticals with improved efficacy and reduced side effects.
Used in Drug Delivery Systems:
1-(Propanoyl)-Piperazine can be incorporated into drug delivery systems to enhance the bioavailability and therapeutic outcomes of pharmaceuticals. Its ability to interact with other molecules and form stable complexes makes it a suitable candidate for the development of novel drug delivery platforms, such as nanoparticles and liposomes.

InChI:InChI=1/C7H14N2O/c1-2-7(10)9-5-3-8-4-6-9/h8H,2-6H2,1H3

Upstream product

• 110-85-0 piperazine 
• 554-12-1 propanoic acid methyl ester 
• 123-62-6 propionic acid anhydride 
• 74-85-1 ethene 
• 1327884-43-4 tert-butyl-4-propionylpiperazine-1-carboxylate 
• 314728-80-8 1-(4-benzyl-piperazin-1-yl)-propan-1-one 

Downstream Products

• 98106-44-6 6-Fluoro-1-(4-fluoro-phenyl)-4-oxo-7-(4-propionyl-piperazin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid 
• 100500-93-4 1-(4-propanoyl-1-piperazinyl)-2-propanone 
• 314728-85-3 Sunifiram 
• 5436-89-5 N,N'-dipropionylpiperazine 
• 1198795-06-0 4-propionylpiperazine-1-carboxylic acid phenylamide 
• 1198795-05-9 4-propionylpiperazine-1-carboxylic acid phenyl ester 
• 1198795-07-1 1-(4-phenylacetylpiperazin-1-yl)propan-1-one 
• 1259916-98-7 N-cyclohexyl-2-(4-propionylpiperazin-1-yl)acetamide 

Relevant academic research and scientific papers

Benzofuran derivative as well as preparation method and medical application thereof

The invention relates to benzofuran derivatives, and a preparation method and medical application thereof. Specifically, the present invention relates to a new benzofuran derivative represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and application of the composition as a therapeutic agent, especially as a PAR-4 antagonist, wherein each substituent of general formula (I) is as defined in the specification.

Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)- 2H-phthalazin-1-ones as potent PARP-1 inhibitors

We have developed a series of substituted 4-(thiophen-2-ylmethyl)-2H- phthalazin-1-ones as potent PARP-1 inhibitors. Preliminary biological evaluation indicated that most compounds possessed inhibitory potencies comparable to, or higher than AZD-2281. Among these compounds, 18q appeared to be the most notable one, which displayed an 8-fold improvement in enzymatic activity compared to AZD-2281. These efforts lay the foundation for our further investigation.

CYCLIC AMINES AS BROMODOMAIN INHIBITORS

The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

New antiproliferative benzoindolinothiazepines derivatives

New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.

Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity

Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1,4-diazabicyclo[4.3.0]nonan-9-one, as the compounds of the new series maintain high nootropic activity. Moreover molecular simplification produces more clear-cut structure-activity relationships with respect to the parent series. The mechanism of action also appears to be similar in the two series. In fact, although the molecular mechanism remains to be elucidated, the most potent compound of each class (DM232 and 13, DM235) is able to increase acetylcholine release in rat brain. Piperazine derivatives represent a new class of nootropic drugs with an in vivo pharmacological profile very similar to that of piracetam, showing much higher potency with respect to the reference compound. Among the compounds studied, 13 (DM235) shows outstanding potency, being active at a dose of 0.001 mg kg-1 sc.

Process for one-step synthesis of amides

A N-alkyl amide derivative is synthesized in one-step by reacting an olefin, nitrogen-containing compound and carbon monoxide with a catalyst comprising a rhodium-containing compound in the presence of water at a pressure of at least 500 psi and a temperature of at least 50° C.

Synthesis and pharmacologic activity of derivatives of 3-aminopropiophenone and 3-aminomethylcamphor

As a part of a research on analgesic compounds 0-(4-methoxyphenyl)carbamoyl-3-aminopropiophenone oximes, 0-(4-methoxyphenyl)-carbamoyl-3-aminomethylcamphor oximes and 4-(4-methoxyphenyl)semicarbazones of 3-aminopropiophenones were prepared. The analgesic activity of these compounds was tested and the results of pharmacological screening are discussed.

SYNTHESES OF PIPERAZINES SUBSTITUTED ON THE NITROGEN ATOMS WITH ALLYL, PROPYL, 2-HYDROXYPROPYL AND 3-HYDROXYPROPYL GROUPS

The paper describes synthesis of 1,4-diallylpiperazine (I), 1-allylpiperazine (III), 1-propylpiperazine (IV), 1-(1-piperazinyl)-2-propanol (V), 3-(1-piperazinyl)-1-propanol (VI), 1-allyl-4-propylpiperazine (VII), 1-(4-allyl-1-piperazinyl)-2-propanol (VIII), 3-(4-allyl-1-piperazinyl)-1-propanol (IX), 1,4-dipropylpiperazine (X), 1-(4-propyl-1-piperazinyl)-2-propanol (XI), 3-(4-propyl-1-piperazinyl)-1-propanol (XII), 1,4-bis(2-hydroxypropyl)piperazine (XIII), 3--1-propanol (XIV) and 1,4-bis(3-hydroxypropyl)piperazine (XV).Retention indices of I-XV are reported and mass spectra of the compounds are discussed.