Journal of the Chemical Society. Perkin transactions I p. 2629 - 2632 (1996)
Update date:2022-08-30
Topics:
Cao, Zhisong
The new camptothecin derivatives (20S)-20-O-acetyl-14-nitrocamptothecin 7 and 5-hydroxy-14-nitrocamptothecin 8 are prepared by the reactions of camptothecin 1 with nitronium tetrafluoroborate 9 in acetic anhydride and trifluoroacetic acid, respectively. When acetic acid is used as reaction solvent, the esterification product (20S)-20-O-acetylcamptothecin 6 is obtained.
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