76929-37-8Relevant academic research and scientific papers
Direct synthesis of polysubstituted 2-aminothiophenes by Cu(ii)-catalyzed addition/oxidative cyclization of alkynoates with thioamides
Ge, Li-Shi,Wang, Zheng-Lin,An, Xing-Lan,Luo, Xiaoyan,Deng, Wei-Ping
, p. 8473 - 8479 (2014/12/10)
A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(ii)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere. This journal is
Optically active thiophenes via an organocatalytic one-pot methodology
Ransborg, Lars Krogager,Albrecht, Lukasz,Weise, Christian F.,Bak, Jesper R.,Jorgensen, Karl Anker
supporting information; experimental part, p. 724 - 727 (2012/04/11)
A general methodology for the synthesis of trisubstituted, optically active thiophenes by an organocatalytic one-pot reaction cascade is presented. The target products are synthesized in good yields (up to 92%) and with excellent enantioselectivities (up to 98% ee). Importantly, based on practical and easily available starting materials, the presented methodology can be conducted under mild reaction conditions. To further elucidate the generality, the synthesis of optically active thienoindoles, as well as selenophenes, is also demonstrated.
Two-carbon extension of N,N-disubstituted amides with bis(trimethylsilyl) thioketene affording N,N-disubstituted 3-oxothioamides
Tsuchiya, Tohru,Oishi, Akihiro,Shibuya, Isao,Taguchi, Yoichi,Honda, Kazumasa
, p. 1621 - 1622 (2007/10/03)
N,N-Disubstituted alkanamides cleanly react with bis(trimethylsilyl)thioketene to form N,N-disubstituted 2-trimethylsilyl-3-trimethylsilyloxyalk-2-enethioamides, which upon acid hydrolysis give N,N-disubstituted 3-oxoalkanethioamides.
