96328-02-8

Basic information

• Product Name: 3-hydroxy-N,N-dimethyl-3-phenylpropanamide
• CAS NO: 96328-02-8
• Molecular Weight: 193.246
• Mol File: 96328-02-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-N,N-dimethyl-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-N,N-dimethyl-3-phenylpropanamide(96328-02-8)
• EPA Substance Registry System: 3-hydroxy-N,N-dimethyl-3-phenylpropanamide(96328-02-8)

Safety Data

• Hazardous Substances Data: 96328-02-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 18871-71-1 N,N-dimethyl 3-oxo-3-phenyl-propanamide 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 98-86-2 acetophenone 
• 23184-28-3 N,N-dimethyl(trimethylsilyl)acetamide 
• 1191104-08-1 N,N-dimethyl-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanamide 
• 5908-41-8 benzoyltrimethylsilane 
• 127-19-5 N,N-dimethyl acetamide 

Downstream Products

• 26218-50-8 N,N-dimethyl-3-phenylpropiolamide 
• 86-21-5 pheniramine 
• 76929-37-8 N,N-dimethyl-3-oxo-3-phenylpropanethioamide 
• 18871-71-1 N,N-dimethyl 3-oxo-3-phenyl-propanamide 
• 1354724-78-9 (R)-(2-(dimethylamino)-5-(1-hydroxyheptyl)thiophen-3-yl)(phenyl)methanone 
• 1354724-77-8 (R)-N-(1-(4-benzoyl-5-(dimethylamino)thiophen-2-yl)heptyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes

Direct synthesis of alkynes from inexpensive, abundant alcohols was achieved in high yields (greater than 40 examples, up to 95% yield) through a SO2F2-promoted dehydration and dehydrogenation process. This straightforward transformation of sp3-sp3 (C-C) bonds to sp-sp (C=C) bonds requires only inexpensive and readily available reagents (no transition metals) under mild conditions. The crude alkynes are sufficiently free of impurities to permit direct use in further transformations, as illustrated by regioselective Huisgen alkyne-azide cycloaddition reactions with PhN3 to give 1,4-substituted 1,2,3-traiazoles (16 examples, up to 92% yield) and Sonogashira couplings (10 examples, up to 77% yield).

Optically active thiophenes via an organocatalytic one-pot methodology

A general methodology for the synthesis of trisubstituted, optically active thiophenes by an organocatalytic one-pot reaction cascade is presented. The target products are synthesized in good yields (up to 92%) and with excellent enantioselectivities (up to 98% ee). Importantly, based on practical and easily available starting materials, the presented methodology can be conducted under mild reaction conditions. To further elucidate the generality, the synthesis of optically active thienoindoles, as well as selenophenes, is also demonstrated.

Amide enolate additions to acylsilanes: In situ generation of unusual and stereoselective homoenolate equivalents

The synthesis of β-hydroxy carbonyl compounds is an important goal due to their prevalence in bioactive molecules. A novel approach to construct these structural motifs involves the multicomponent reaction of acylsilanes, amides, and electrophiles. The ad