7697-61-2Relevant academic research and scientific papers
Enantioselective Bromolactonization of Trisubstituted Olefinic Acids Catalyzed by Chiral Pyridyl Phosphoramides
Nishikawa, Yasuhiro,Hamamoto, Yuhta,Satoh, Rika,Akada, Naho,Kajita, Shuhei,Nomoto, Marina,Miyata, Megumi,Nakamura, Madoka,Matsubara, Chinatsu,Hara, Osamu
, p. 18880 - 18885 (2018/12/04)
Enantioselective bromolactonization of trisubstituted olefinic acids producing synthetically useful chiral lactones with two contiguous asymmetric centers has remained mainly unexplored except for the 6-exo cyclization mode. In this work, the 5-exo- and 6
Expedient Access to 2,3-Dihydropyridines from Unsaturated Oximes by Rh(III)-Catalyzed C-H Activation
Romanov-Michailidis, Fedor,Sedillo, Kassandra F.,Neely, Jamie M.,Rovis, Tomislav
, p. 8892 - 8895 (2015/08/03)
α,β-Unsaturated oxime pivalates are proposed to undergo reversible C(sp2)-H insertion with cationic Rh(III) complexes to furnish five-membered metallacycles. In the presence of 1,1-disubstituted olefins, these species participate in irreversible migratory insertion to give, after reductive elimination, 2,3-dihydropyridine products in good yields. Catalytic hydrogenation can then be used to convert these molecules into piperidines, which are important structural components of numerous pharmaceuticals.
Flexible, phase-transfer catalyzed approaches to 4-substituted prolines
Johnston, Heather J.,McWhinnie, Fergus S.,Landi, Felicetta,Hulme, Alison N.
, p. 4778 - 4781 (2015/04/27)
A range of 4-substituted prolines can be rapidly synthesized from a protected glycine Schiff base in only four steps and in 27-55% overall yield. Phase transfer catalysis allows direct access to both enantiomeric series, and the relative stereochemistry at the 4-position is readily controlled (>10:1 dr) through the choice of hydrogenation conditions.
Catalytic, enantioselective, and highly chemoselective bromocyclization of olefinic dicarbonyl compounds
Zhao, Yi,Jiang, Xiaojian,Yeung, Ying-Yeung
, p. 8597 - 8601 (2013/09/12)
Overriding preferences: An amine-thiocarbamate catalyst can mediate the facile, efficient, and highly enantioselective bromocyclization of olefinic 1,3-dicarbonyl compounds. In the presence of the bifunctional catalyst, the bromination occurs chemoselectively at the olefinic moiety rather than at the carbon atom in the α-position to the carbonyl units. Copyright
α, β-unsaturated ketones
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, (2008/06/13)
The present invention relates to new α,β-unsaturated ketones of formula I. The new compounds exhibit an intense, very long lasting green galbanum-type odor with fruity undertones. Compositions containing these novel compounds are also provided.
