76979-43-6

Basic information

• Product Name: 5-(4-Methoxyphenylmethylene)-2-(phenylmethylimino)-4-thiazolidinone
• Synonyms: 5-(4-Methoxyphenylmethylene)-2-(phenylmethylimino)-4-thiazolidinone
• CAS NO: 76979-43-6
• Molecular Weight: 324.403
• Mol File: 76979-43-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-Methoxyphenylmethylene)-2-(phenylmethylimino)-4-thiazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Methoxyphenylmethylene)-2-(phenylmethylimino)-4-thiazolidinone(76979-43-6)
• EPA Substance Registry System: 5-(4-Methoxyphenylmethylene)-2-(phenylmethylimino)-4-thiazolidinone(76979-43-6)

Safety Data

• Hazardous Substances Data: 76979-43-6(Hazardous Substances Data)

Upstream product

• 622-78-6 Benzyl isothiocyanate 
• 123-11-5 4-methoxy-benzaldehyde 
• 17385-69-2 2-(benzylimino)thiazolidin-4-one 
• 5462-97-5 5-(4-methoxybenzylidene)-2-thioxo-4-thiazolidinone 
• 28996-11-4 5-(4-methoxy-benzylidene)-2-methylsulfanyl-thiazol-4-one 
• 100-46-9 benzylamine 

Downstream Products

• 76979-51-6 5-(4-Methoxyphenylmethylene)-2-(phenylmethylimino)-3-methyl-4-thiazolidinone 

Relevant articles and documents

Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors

In this work, iminothiazolidin-4-one derivatives were explored as selective GSK-3β inhibitors. Molecular docking analysis was carried to design a series of compounds, which were synthesized using substituted thiourea, 2-bromoacetophenones and benzaldehydes. Out of the twenty five compounds synthesized during this work, the in?vitro evaluation against GSK-3 led to the identification of nine compounds with activity in lower nano-molar range (2–85?nM). Further, in?vitro evaluation against CDK-2 showed five compounds to be selective towards GSK-3.