7699-22-1

Usage

Type of compound

Chemical compound

Derivative of

Indole (a heterocyclic aromatic organic compound)

Also known as

5-methoxytryptophol

Occurrence

Naturally occurring alkaloid found in various plant species

Psychoactive properties

Potential sedative and hallucinogenic effects

Therapeutic applications

Studied for treating mood disorders and substance abuse

Role in biosynthesis

Involved in the biosynthesis of serotonin, a neurotransmitter regulating mood, appetite, and sleep

Upstream product

• 75-75-2 methanesulfonic acid 
• 148518-74-5 N-methyl-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide 
• 7699-18-5 5-methoxyindolin-2-one 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 148518-76-7 N-benzyl-N-(3,4-dimethoxyphenyl)-α-carbomethoxy-α-diazoacetamide 

Downstream Products

• 110554-80-8 3-(4-diethylamino-phenylimino)-5-methoxy-1-methyl-indolin-2-one 
• 6062-24-4 1-methyl-5-hydroxy-2-indolinone 

Relevant academic research and scientific papers

KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME

The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.

Effects of catalysts on the cyclization of 2-diazo-2-methoxycarbonyl-N-aryl-N-alkylethanamides

Inorganic solids have pronounced effects on the product distribution from decomposition of the title compounds; zeolite Kβ is particularly useful for directing the synthesis of indolinones such as 5-methoxy-N-methylindolin-2-one, which is formed in 89% yield from 2-diazo-2-methoxycarbonyl-N-(4-methoxyphenyl)-N-methylethanamide; speculation is made about a possible mechanism.

Substituted oxindoles

The present invention relates to novel substituted oxindoles of the formula I as defined below and related compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds as inhibitors of phosphodiesterase ("PDE") type IV. The compounds of this invention are useful in the treatment of AIDS, asthma, rheumatoid arthritis, osteoarthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, atopic, dermatitis, shock, other inflammatory diseases, and other conditions where the action of phosphodiesterase type IV is implicated.

The Nafion-H Catalysed Cyclization of α-Carbomethoxy-α-Diazoacetanilides. Synthesis of 3-Unsubstituted-2-Indolinones.

Diazoanilides of type 4 were found to undergo Nafion-H catalysed cyclization onto the aromatic ring and concomitant decarboxylation, under optimal conditions, to give 3-unsubstituted 2-indolinones 5 in moderate yields.Diazoanilides that possess electron-donating substituents in the aromatic moiety gave higher yields of 5 and, in one case, the presence of an electron-withdrawing group in the aromatic moiety did not impede the cyclization.In the case of the diazoanilides that possess a N-butenyl group, preferential 1,3-dipolar cycloaddition of the diazo unit onto the butenyl double bond occurred to give an unstable 1-pyrazoline which was converted, by loss of nitrogen accompanied by hydrogen migration, to dihydro-2-pyridinone derivatives.It was also found that substituents ortho to the amido group and/or the site of cyclization sterically retarded the cyclization.