5-Methoxy-1-methylindolin-2-one

Base Information

• Chemical Name: 5-Methoxy-1-methylindolin-2-one
• CAS No.: 7699-22-1
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• DSSTox Substance ID: DTXSID301251976
• Nikkaji Number: J780.261G

Synonyms:5-methoxy-1-methylindolin-2-one;7699-22-1;2H-Indol-2-one, 1,3-dihydro-5-methoxy-1-methyl-;5-methoxy-1-methyl-3H-indol-2-one;N-methyl-5-methoxyoxindole;SCHEMBL578369;1,3-DIHYDRO-5-METHOXY-1-METHYL-2H-INDOL-2-ONE;5-methoxy-1-methyl-2-indolinone;YXVGOFNUARFVQV-UHFFFAOYSA-N;DTXSID301251976;5-methoxy-1-methyl-1,3-dihydro-2H-indol-2-one;5-methoxy-1-methyl-2,3-dihydro-1H-indol-2-one;Z168882264

Chemical Property of 5-Methoxy-1-methylindolin-2-one

Chemical Property:

• PSA: 29.54000
• LogP: 1.27910
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 217

Purity/Quality:

99% ^*data from raw suppliers

5-METHOXY-1-METHYL-1,3-DIHYDRO-2H-INDOL-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(=O)CC2=C1C=CC(=C2)OC

Technology Process of 5-Methoxy-1-methylindolin-2-one

There total 7 articles about 5-Methoxy-1-methylindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-methoxyindolin-2-one (7699-18-5) + methyl iodide (74-88-4) → 5-methoxy-1-methylindolin-2-one (7699-22-1)

Guidance literature:

With potassium carbonate; In acetone;

Reference yield: 53.0%

5-methoxyindolin-2-one (7699-18-5) + dimethyl sulfate (77-78-1) → 5-methoxy-1-methylindolin-2-one (7699-22-1)

Guidance literature:

5-methoxyindolin-2-one; With sodium hydride; In toluene; mineral oil; at 100 ℃; for 0.5h;

dimethyl sulfate; In toluene; mineral oil; at 100 ℃; for 2.5h;

Reference yield: 37.0%

N-benzyl-N-(3,4-dimethoxyphenyl)-α-carbomethoxy-α-diazoacetamide (148518-76-7) → 5-methoxy-1-methylindolin-2-one (7699-22-1) + 3-Methoxycarbonyl-1-(4-methoxyphenyl)azetidin-2-one

Guidance literature:

In toluene; for 20h; Heating;

DOI:10.1016/S0040-4020(01)80781-X

upstream raw materials:

N-benzyl-N-(3,4-dimethoxyphenyl)-α-carbomethoxy-α-diazoacetamide

methanol

N-methyl-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

methanesulfonic acid

Downstream raw materials:

3-(4-diethylamino-phenylimino)-5-methoxy-1-methyl-indolin-2-one

1-methyl-5-hydroxy-2-indolinone

C₂₄H₂₁N₃O₄S

C₂₅H₂₃N₃O₄S

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