7703-91-5

Basic information

• Product Name: 6-methoxy-1-methylindolin-2-one
• CAS NO: 7703-91-5
• Molecular Weight: 177.203
• Mol File: 7703-91-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-methoxy-1-methylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-1-methylindolin-2-one(7703-91-5)
• EPA Substance Registry System: 6-methoxy-1-methylindolin-2-one(7703-91-5)

Safety Data

• Hazardous Substances Data: 7703-91-5(Hazardous Substances Data)

Upstream product

• 65836-81-9 N-chloroacetyl-N-methyl-m-anisidine 
• 124-38-9 carbon dioxide 
• 156267-11-7 5-methoxy-2-methyl-N-methylaniline 
• 35162-27-7 6-methoxy-1-methyl-1H-indole-2,3-dione 
• 52351-75-4 6-methoxyisatin 
• 14318-66-2 3-methoxy-N-methylaniline 
• 29242-84-0 2-chloro-4-methoxyaniline 
• 156267-21-9 (5-Methoxy-2-methyl-phenyl)-methyl-carbamic acid benzyl ester 
• 156267-17-3 (5-Methoxy-2-methyl-phenyl)-carbamic acid benzyl ester 
• 93646-24-3 N-(2-Chloro-4-methoxy-phenyl)-N-methyl-acetamide 

Downstream Products

• 1373243-45-8 5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one 
• 1373243-46-9 5'-(1-(4-fluorobenzyl)-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl-spiro[cyclopropane-1,3'-indolin]-2'-one 
• 1373242-16-0 C₂₇H₂₁FN₂O₃ 
• 158719-26-7 2,2'-dithiobis [N-phenyl-6-acetoxy-1-methylindolyl-3-carboxamide] 
• 1026065-90-6 Acetic acid 1-methyl-3-phenylcarbamoyl-2-thioxo-2,3-dihydro-1H-indol-6-yl ester 
• 13383-73-8 6-hydroxy-1-methyl-indolin-2-one 

Relevant articles and documents

SPIROCYCLIC COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS

The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions modulated by VGSCs. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions by modulators of VGSC of Formula (I).

Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide)

A series of indole-substituted 2,2'-dithiobis(1-methyl-N-phenyl-1H- indole-3-carboxamides) were prepared and evaluated for their ability to inhibit the tyrosine kinase activity of both the epidermal growth factor receptor (EGFR) and the nonreceptor pp60(v-src) tyrosine kinase. The compounds were synthesized by conversion of appropriate 1-methyloxindoles to 1-methyl-2-indolinethiones with P2S5 followed by subsequent reaction with NaH and phenyl isocyanate and oxidative dimerization of the resulting 2,3- dihydro-N-phenyl-2-thioxo-1H-indole-3-carboxamides. The parent compound and many of the substituted analogues were moderately potent inhibitors of both kinase enzymes, but no clear relationships were seen between substitution on the indole ring and inhibitory activity. While 4-substituted compounds were generally inactive, 5-substituted derivatives with electron-withdrawing groups showed inhibitory activity. However, none of the substituted compounds showed significantly better activity than the unsubstituted parent compound. There was generally a good correlation between activity against the EGFR and pp60(v-src) kinases, but several compounds did show some specificity (>20- fold) of inhibition; 5-Cl and 5-Br derivatives preferentially inhibited pp60(v-src), while the 5-CF3 compound preferentially inhibited EGFR. Selected compounds from the series were found to inhibit the growth of Swiss 3T3 fibroblasts with IC50s in the range 2-25 μM, the most active being 4- substituted derivatives. The compounds inhibited bFGF-mediated protein tyrosine phosphorylation in intact cells more effectively than EGFR- or PDGF- mediated phosphorylation.

Photochemical synthesis of 1,2,3,4-tetrahydroisoquinolin-3-ones and oxindoles from N-chloroacetyl derivatives of benzylamines and anilines. Role of intramolecular exciplex formation and cis conformation of amide bonds

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