77037-40-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzofurancarboxylic acid, 4,6-dimethylis used as a pharmaceutical intermediate for its antimicrobial and anticancer properties. Its biological activities make it a promising candidate for the development of new drugs targeting a range of diseases, including infections and cancer.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Benzofurancarboxylic acid, 4,6-dimethylis utilized as a building block in the synthesis of various organic compounds with potential applications in crop protection and pest control. Its unique structure allows for the creation of new agricultural chemicals that can effectively manage pests and diseases in crops.
Used in Organic Synthesis:
2-Benzofurancarboxylic acid, 4,6-dimethylserves as a valuable starting material in organic synthesis, enabling the development of a wide range of organic compounds with diverse applications. Its unique molecular structure allows for the creation of new compounds with potential uses in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 855613-94-4 2-diazo-1-(4,6-dimethyl-benzofuran-2-yl)-ethanone 
• 856180-07-9 4,6-dimethyl-benzofuran-2-carbonyl chloride 
• 1666-02-0 2-hydroxy-4,6-dimethylbenzaldehyde 
• 1432644-46-6 ethyl (2-formyl-3,5-dimethylphenoxy)acetate 
• 105-36-2 ethyl bromoacetate 
• 108-68-9 3,5-Dimethylphenol 

Downstream Products

• 856180-07-9 4,6-dimethyl-benzofuran-2-carbonyl chloride 
• 77037-41-3 3-(2-hydroxy-4,6-dimethylphenyl)propynoic acid 
• 855613-94-4 2-diazo-1-(4,6-dimethyl-benzofuran-2-yl)-ethanone 
• 1432642-54-0 N-hexyl-4,6-dimethylbenzofuran-2-carboxamide 
• 1432642-46-0 C₁₈H₂₁NO₂ 
• 1432642-24-4 N-cycloheptyl-4,6-dimethylbenzofuran-2-carboxamide 
• 1432642-31-3 N-cyclooctyl-4,6-dimethylbenzofuran-2-carboxamide 
• 1432642-39-1 N-(1-adamantyl)-4,6-dimethylbenzofuran-2-carboxamide 
• 14002-99-4 5,7-dimethyl-2H-1-benzopyran-2-one 

Relevant academic research and scientific papers

Mixture, polymer, optical film, optically anisotropic body, polarizing sheet, display device, antireflective film, and manufacturing method for mixture

A purpose of the present invention is to provide a means by which a polymer can be efficiently manufactured, said polymer being able to be used in the production of an optical film or similar with good reverse wavelength dispersion. In a mixture according to the present invention, the included amount of a polymerizable compound (I) indicated by formula (I) is greater than 0.2 times the included amount of a polymerizable compound (II) indicated by formula (II). (In the formulas, Ar1 and Ar2 are prescribed ring groups; A1-A4 and B1-B4 are cyclic aliphatic groups or aromatic groups and can have a substituent group; Z1-Z4, Y1-Y4, and L1-L4 are prescribed groups such as -O-, -C(=O)-O-, or -O-C(=O)-; R1-R6 are hydrogen atoms, methyl groups, or chlorine atoms; one of e and f is an integer from 1 to 3 and the other is an integer from 0 to 3; c, d, i, and j are integers from 1 to 20; and a, b, g, and h are 0 or 1).

Composition and optical film (by machine translation)

The present invention provides a film forming property excellent composition for manufacturing optical film, and optical film formed by said composition. The invention is to offer a kind of containing the following (A), (B) and a composition (C), said composition and the optical film formed by: (A) said formula (A) compound: (A) [In the formula, Aromatic heterocyclic ring typebase and so on that Y1; D1 and D2 (=O) - O - said, - C; G1 and G2 alicyclic hydrocarbyl, said; In L1 and L2 for at least one of the organic radical having a polymerizable group]; (B) with a mercapto compound; and (C) photo-polymerization initiator. (by machine translation)

INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.

Preliminary structure - Activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains

Tuberculosis (TB) remains one of the leading causes of mortality and morbidity worldwide, with approximately one-third of the world's population infected with latent TB. This is further aggravated by HIV coinfection and the emergence of multidrug- and extensively drug-resistant (MDR and XDR, respectively) TB; hence the quest for highly effective antitubercular drugs with novel modes of action is imperative. We report herein the discovery of an indole-2-carboxamide analogue, 3, as a highly potent antitubercular agent, and the subsequent chemical modifications aimed at establishing a preliminary body of structure-activity relationships (SARs). These efforts led to the identification of three molecules (12-14) possessing an exceptional activity in the low nanomolar range against actively replicating Mycobacterium tuberculosis, with minimum inhibitory concentration (MIC) values lower than those of the most prominent antitubercular agents currently in use. These compounds were also devoid of apparent toxicity to Vero cells. Importantly, compound 12 was found to be active against the tested XDR-TB strains and orally active in the serum inhibition titration assay.