1666-02-0

Basic information

• Product Name: 4,6-DiMethyl-2-hydroxybenzaldehyde
• Synonyms: 4,6-DiMethyl-2-hydroxybenzaldehyde;4,6-Dimethylsalicylaldehyde;6-Hydroxy-2,4-dimethylbenzaldehyde
• CAS NO: 1666-02-0
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.1745
• Mol File: 1666-02-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 48-49 °C(Solv: methanol (67-56-1))
• Boiling Point: 140 °C(Press: 29 Torr)
• Appearance: /
• Density: 1.136±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.39±0.15(Predicted)
• CAS DataBase Reference: 4,6-DiMethyl-2-hydroxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DiMethyl-2-hydroxybenzaldehyde(1666-02-0)
• EPA Substance Registry System: 4,6-DiMethyl-2-hydroxybenzaldehyde(1666-02-0)

Safety Data

• Hazardous Substances Data: 1666-02-0(Hazardous Substances Data)

Usage

General Description

4,6-Dimethyl-2-hydroxybenzaldehyde, also known as veratraldehyde, is a chemical compound with the molecular formula C9H10O2. It is a colorless to pale yellow liquid with a strong, sweet, vanilla-like odor. Veratraldehyde is commonly used as a flavoring agent in the food industry, particularly in the production of vanilla and as a fragrance ingredient in perfumes and cosmetics. It is also used as a precursor in the synthesis of pharmaceuticals and agrochemicals. Additionally, veratraldehyde has potential applications in the production of polymers, resins, and other industrial products. However, it is important to handle this chemical with care as it is highly flammable and may cause skin and eye irritation upon contact.

Upstream product

• 100-97-0 hexamethylenetetramine 
• 108-68-9 3,5-Dimethylphenol 
• 67-66-3 chloroform 
• 83612-61-7 3,5-dimethyl-2,4-hexadienoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 13460-50-9 metaboric acid 
• 56-81-5 glycerol 
• 7446-70-0 aluminium trichloride 
• 71-43-2 benzene 
• 74-90-8 hydrogen cyanide 
• 50-00-0 formaldehyd 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 129001-70-3 4-(benzyloxy)-3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl 
• 78347-36-1 3-nitro-4,6-dimethylsalicylaldehyde 
• 78347-35-0 5-nitro-4,6-dimethylsalicylaldehyde 
• 1148037-09-5 C₁₂H₁₂O₂ 
• 77037-40-2 4,6-dimethyl-1-benzofuran-2-carboxylic acid 
• 51926-66-0 2-methoxy-4,6-dimethoxybenzyl alcohol 
• 433331-69-2 4'-(3-Benzoyloxypropyl)-2-(methoxymethyloxy)-4,6-dimethyldiphenylmethane 
• 433331-67-0 4'-(3-Benzyloxypropyl)-2-(methoxymethyloxy)-4,6-dimethyldiphenylmethanol 
• 449146-64-9 4'-(3-Hydroxypropyl)-2-(methoxymethyloxy)-4,6-dimethyldiphenylmethane 
• 433331-70-5 2-[4-(3-benzoyloxypropyl)benzyl]-3,5-dimethylphenol 

Relevant articles and documents

Inhibition of Urease, a Ni-Enzyme: The Reactivity of a Key Thiol With Mono- and Di-Substituted Catechols Elucidated by Kinetic, Structural, and Theoretical Studies

The inhibition of urease from Sporosarcina pasteurii (SPU) and Canavalia ensiformis (jack bean, JBU) by a class of six aromatic poly-hydroxylated molecules, namely mono- and dimethyl-substituted catechols, was investigated on the basis of the inhibitory efficiency of the catechol scaffold. The aim was to probe the key step of a mechanism proposed for the inhibition of SPU by catechol, namely the sulfanyl radical attack on the aromatic ring, as well as to obtain critical information on the effect of substituents of the catechol aromatic ring on the inhibition efficacy of its derivatives. The crystal structures of all six SPU-inhibitors complexes, determined at high resolution, as well as kinetic data obtained on JBU and theoretical studies of the reaction mechanism using quantum mechanical calculations, revealed the occurrence of an irreversible inactivation of urease by means of a radical-based autocatalytic multistep mechanism, and indicate that, among all tested catechols, the mono-substituted 3-methyl-catechol is the most efficient inhibitor for urease.

Two Colour Photoflow Chemistry for Macromolecular Design

We report a photochemical flow setup that exploits λ-orthogonal reactions using two different colours of light (λ1=350 nm and λ2=410 nm) in sequential on-line irradiation steps. Critically, both photochemically reactive units (a visi

Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group

A general synthesis of highly substituted 2-naphthols based on a new carbanionic reaction sequence is demonstrated. The reaction exploits the dual nature of lithium bases consisting of consecutive ring opening of readily available coumarins with either LiNEt2 or LiNiPr2 into Z-cinnamamides, thus generating a directing group in situ and allowing, by conformational freedom, a lateral directed remote metalation for ring closure to give the aryl 2-naphthols in good to excellent yields. These transformations can be combined to provide a more efficient one-pot process. Mechanistic insight into the remote lateral metalation step, demonstrating the requirement of Z-cinnamamide, is described. Application of this methodology to the synthesis of highly substituted 3,3′-diaryl BINOL ligands is also reported.