7706-90-3

Basic information

• Product Name: 4-(4-hydroxyphenyl)furan-2(5H)-one
• CAS NO: 7706-90-3
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.1687
• Mol File: 7706-90-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 416.5°C at 760 mmHg
• Flash Point: 194.8°C
• Density: 1.353g/cm³
• Vapor Pressure: 1.58E-07mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 4-(4-hydroxyphenyl)furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-hydroxyphenyl)furan-2(5H)-one(7706-90-3)
• EPA Substance Registry System: 4-(4-hydroxyphenyl)furan-2(5H)-one(7706-90-3)

Safety Data

• Hazardous Substances Data: 7706-90-3(Hazardous Substances Data)

Upstream product

• 42528-99-4 2,4’-diacetoxyacetophenone 
• 105-36-2 ethyl bromoacetate 
• 71-43-2 benzene 
• 7339-87-9 4-hydroxyphenylacetaldehyde 
• 441287-32-7 3-chloro-4-(4-methoxyphenyl)-2(5H)-furanone 
• 329328-50-9 3-bromo-4-(4-methoxyphenyl)-2(5H)-furanone 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 157123-01-8 trifluoromethanesulfonic acid 5-oxo-2,5-dihydrofuran-3-yl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 3516-65-2 4-(4-methoxyphenyl)furan-2(5H)-one 

Downstream Products

• 30088-79-0 4-(4-acetoxy-phenyl)-5H-furan-2-one 
• 136762-98-6 (Z)-4-(4-hydroxyphenyl)-5-(4-methoxybenzylidene)furan-2(5H)-one 
• 1608121-21-6 (Z)-5-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one 
• 1608121-24-9 (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one 
• 136762-97-5 4-(4-hydroxyphenyl)-5-[(Z)-(4-hydroxyphenyl)methylidene]furan-2-one 
• 3516-65-2 4-(4-methoxyphenyl)furan-2(5H)-one 

Relevant articles and documents

A Rubrolide synthetic method of compound (by machine translation)

The invention discloses a Rubrolide synthetic method of compound, comprises the following steps: (1) under the action of the phosphate, substituted phenylacetaldehydes and chloroacetic acid obtained through the reaction of intermediate 1; (2) the intermediate 1 with NaBH4 Reduction reaction, reduction reaction product is then purged acid dehydration reaction to obtain the intermediate 2; (3) under the action of alkali, the intermediate 2 and substituted benzene formaldehyde reflux reaction to obtain the target product. The present invention provides synthetic method of compound Rubrolide using substituted phenylacetaldehydes, glyoxalic acid, phosphoric acid, NaBH4 And concentrated sulfuric acid as the raw materials, raw materials are cheap, easy to obtain, the synthetic method is simple, mild reaction, compared with the traditional synthetic method, not only to avoid expensive raw materials and a noble metal catalyst, greatly reduces the production cost, and also avoids the harsh reaction conditions; and the mild reaction conditions, the operation is simple, friendly to the environment, the solvent is easily recovered, is suitable for industrial production. (by machine translation)

Palladium-catalyzed hydrodehalogenation of butenolides: An efficient and sustainable access to β-arylbutenolides

Several α-unsubstituted β-arylbutenolides have been prepared in 69–92% yield by reductive dehalogenation of α-halo-β-arylbutenolides. The latter were assembled in a single-step from α,β-dihalobutenolides, which are accessible on a large-scale from biomass-derived furfural. Our dehalogenation protocol is illustrated by a new synthesis of the marine antibiotics rubrolide E and F, and 3″-bromorubrolide F.

Synthetic method for rubrolide compounds E, F, R, S and their derivatives

Rubrolide F (compound 1f), R (compound 1r), and S (compound 1s), which are biological important natural butenolides, 7andPrime;,8andPrime;-didihydro derivatives (compound 1sa) thereof, 3andPrime; -bromorubrolide (compound 1fa), rubrolide E (compound 1e) and di-O-methyl derivatives thereof (compound 1ea) can be industrially obtained and are effectively synthesized with the overall yield of 14-48.5% from low-priced precursors. The rubrolide compounds can be synthesized through a Knoevenagel condensation reaction after a Wittig-Horner reaction and SeO_2-induced tandem allylic hydroxylation/intramolecular cyclization for preparing butenolide rings and a rubrolide cores structure.COPYRIGHT KIPO 2017