7707-06-4Relevant academic research and scientific papers
Metal triflate catalyzed reactions of alkenes, NBS, nitriles, and TMSN 3: Synthesis of 1,5-disubstituted tetrazoles
Hajra, Saumen,Sinha, Debarshi,Bhowmick, Manishabrata
, p. 1852 - 1855 (2007)
A versatile and highly efficient protocol for the synthesis of 1,5-disubstituted tetrazoles has been developed by metal triflate catalyzed one-pot reaction of alkenes, NBS, nitriles, and TMSN3. Among the metal triflates, Zn(OTf)2 was found to be the best catalyst. Use of different combinations of alkenes and nitriles generate a variety of 1,5-disubstituted tetrazoles containing an additional α-bromo functionality of the N1-alkyl substituent.
