91157-97-0

Upstream product

• 61650-82-6 1,2-dichloro-3-methoxy-buta-1,3-diene 
• 134220-08-9 methyl 1,2,2-trichloroethyl ketone 
• 540-59-0 1,2-Dichloroethylene 
• 75-36-5 acetyl chloride 

Downstream Products

• 591233-95-3 1-phenyl-3-methyl-4-chloropyrazole 
• 1006708-35-5 1-chloro-1-(2-phenylhydrazono)propan-2-ol 
• 77070-88-3 3-chloro-4,4-diethoxy-butan-2-one 
• 95093-93-9 2-(1-chloro-2-oxopropyl)dioxolane 

Relevant academic research and scientific papers

Synthesis, structure, and characteristics of 1,2-dichlorovinyl alkyl ketones

A method of alkyl 1,2-dichlorovinyl ketones preparation from acyl halides and 1,2-dichloroethylene was developed. The configurational equilibrium and electronic structure of alkyl 1,2-dichlorovinyl ketones was investigated by IR, 1H and 13C NMR spectroscopy, by measuring dipole moments, and by quantum-chemical calculations using methods RHF and B3LYP in the basis 6-311++G (d,p). Alkyl 1,2-dichlorovinyl ketones are stable in the Z, s-cis-configuration where the olefin proton is involved into an intramolecular hydrogen bond with the oxygen of the carbonyl group. Reaction of 1,2-dichlorovinyl ketones with alkylhydrazines afforded 1-alkyl-3-alkyl-4- chloropyrazoles. The reaction of alkyl 1,2-dichlorovinyl ketones with 1,1-dimethylhydrazine involved dehydrochlorination and afforded 1,1-dimethylhydrazinium hydrochloride and a mixture of compounds with uncertain structure. 2004 MAIK "Nauka/Interperiodica".

2-(N-SUBSTITUTED GUANIDINO)-4-HETERO-ARYLTHIAZOLE ANTIULCER AGENTS

2,4-Disubstituted thiazole compounds of the formula STR1 or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, orX is S and Y is CH;R 1 is certain straight or branched chain alkyl groups, (R 3) 2 C 6 H 3, or (R 3) 2 Ar(CH 2) n where n is an integer from 1 to 4, R 3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups; R 2 is H or (C 1-C 4)alkyl; or R 1 and R 2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; and R 4 is H, (C 1-C 5)alkyl, NH 2 or CH 2 OH; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds.

Synthesis of 2-Substituted 5-Acetyl-1(H)-imidazoles via 3-Chloro-4,4-dimethoxy-2-butanone and Related 3,4-Disubstituted 3-Buten-2-ones

A variety of 3,4-disubstituted 3-buten-2-ones have been synthesized and reacted with acetamidine to yield 5-acetyl-2-methyl-1(H)-imidazoles, 5-substituted pyrimidines, or both.The nature of the product depends on the substituents at position 3 and 4 of th

Process for preparation of 4-acetyl-2-substituted-imidazoles

Novel intermediates of the formula STR1 where R1 and R2 are each (C1 -C4)alkyl or taken together are (C2 -C4)alkylene, and their use in a process for preparation of compounds of the formula STR2 where R is (C1 -C6)alkyl or (CH2)n Ar, Ar is phenyl or phenyl monosubstituted by Cl, Br, F, CH3 or OCH3 and n is 2 to 4; which comprises contacting one of said intermediates with an amidine of formula STR3 in the presence of reaction inert solvent and base; and a process for preparing a further intermediate, 1,2-dichloro-1-buten-3-one.