770741-96-3

Upstream product

• 3744-80-7 cyclopent-3-ene-1-carboxylic acid chloride 
• 676517-53-6 4-(3,4-dichlorophenoxy)-1-[(3,4-dihydroxycyclopentyl)carbonyl]piperidine 
• 676517-52-5 1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)piperidine 
• 245057-73-2 4-(3,4-dichloro-phenoxy)-piperidine 

Downstream Products

• 770741-25-8 C₂₇H₃₃Cl₂FN₂O₃ 
• 921204-75-3 methyl (2S)-2-[4-[[4-(3,4-dichlorophenoxy)-1-piperidyl]methyl]-1-piperidyl]-2-methyl-3-phenylpropanoate 
• 921204-71-9 methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate 
• 676517-68-3 methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate 
• 676518-10-8 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(S)-phenyl-1-piperidineacetic acid 

Relevant academic research and scientific papers

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.