921204-75-3

Upstream product

• 3744-80-7 cyclopent-3-ene-1-carboxylic acid chloride 
• 676517-50-3 4-[4-(3,4-dichloro-phenoxy)-piperidin-1-ylmethyl]-cyclopentane-1,2-diol 
• 676517-53-6 4-(3,4-dichlorophenoxy)-1-[(3,4-dihydroxycyclopentyl)carbonyl]piperidine 
• 676517-52-5 1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)piperidine 
• 245057-73-2 4-(3,4-dichloro-phenoxy)-piperidine 
• 770741-96-3 C₁₇H₂₁Cl₂NO₃ 
• 28385-45-7 L-α-methylphenylalanine methyl ester 
• 921204-74-2 (+/-)-methyl 2-[4-[[4-(3,4-dichlorophenoxy)-1-piperidyl]methyl]-1-piperidyl]-2-methyl-3-phenylpropanoate 

Downstream Products

• 921204-45-7 C₂₇H₃₄Cl₂N₂O₃ 

Relevant academic research and scientific papers

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.

NOVEL PIPERIDINE DERIVATIVES

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) mediated disease state.