770743-83-4

Upstream product

• 794567-06-9 (1S,5R)-5-methyl-2-(p-tolylsulfonyl)-6-oxa-2-aza-bicyclo[3.2.0]heptan-7-one 
• 67-56-1 methanol 
• 794567-08-1 (2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 63366-76-7 (toluene-4-sulfonylamino)acetic acid benzyl ester 
• 770743-80-1 (R)-(+)-N-(p-toluenesulfonyl)-2-phenyl-3,3-(propanedisulfanyl)pyrrolidine 
• 770743-82-3 (2R,3R)-(-)-3-methyl-2-phenyl-1-(toluene-4-sulfonyl)pyrrolidin-3-ol 
• 770743-81-2 (R)-(-)-2-phenyl-1-(toluene-4-sulfonyl)pyrrolidin-3-one 

Downstream Products

• 681236-64-6 (2S,3R)-3-hydroxy-3-methylpyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

A short-step synthesis of (2S,3R)-3-hydroxy-3-methylproline, a component of polyoxypeptins, using a tandem Michael-aldol reaction and optical resolution

A short-step synthesis of (2S,3R)-3-hydroxy-3-methylproline, a component of polyoxypeptins, using a tandem Michael-aldol reaction followed by its optical resolution using (-)-cinchonidine has been achieved.

Asymmetric synthesis of α-amino 1,3-dithioketals from sulfinimines (N-sulfinyl imines). Synthesis of (2S,3R)-(-)-3-hydroxy-3-methylproline

(Chemical Equation Presented) N-Sulfinyl α-amino 1,3-dithioketals are prepared in high de and good yield by treating sulfinimines with lithio-1,3-dithianes. Selective removal of the N-sulfinyl or the thioketal groups affords stable α-amino 1,3-dithioketal